Zhou S, Zhang Y, Davie A, Marshall-Gradisnik S, Hu H, Wang J, Brushett D
School of Exercise Science and Sport Management, Southern Cross University, Lismore, Australia.
J Sports Med Phys Fitness. 2005 Sep;45(3):337-46.
To investigate whether 4 weeks of oral supplementation with coenzyme Q10 (CoQ10) would increase its concentration in skeletal muscle, and affect aerobic power (VO2max) and oxygen consumption during submaximal exercise in healthy, physically active men.
Six volunteers with an average (+/-SD) age of 29.7+/-7.2 years and VO2max of 39.4+/-8.5 mL.kg-1.min-1, participated in a single-blind trial. The experiment consisted of 4 2-week phases, in the order of placebo run-in, CoQ10 supplementation (150 mg daily), CoQ10 (150 mg) plus vitamin E (1,000 IU daily), and placebo wash-out. A three-stage cycle economy test (4 minutes at each of 50, 100, and 150 watts), followed by a VO2max test (25 watts increment every minute till exhaustion), were performed prior to the supplementation and at the end of each phase. Blood samples were taken pre and post each VO2max test, and biopsy samples were obtained from the vastus lateralis muscle pre and post the 4 weeks of CoQ10 supplementation.
The plasma CoQ10 concentration was significantly elevated by the supplementation (P<0.05), however, it did not vary significantly pre and post each exercise test (P>0.05). The muscle CoQ10 concentration, VO2max ventilatory threshold, exercise economy and oxygen deficit showed no significant changes in response to the supplementation.
It was speculated that the non-significant effects of supplementation in healthy, non CoQ10-deficient men could be due to either that the mitochondrial membrane is normally saturated with CoQ10, or that the selected exercise testing protocol and variables were not sensitive enough to detect the effects.
研究口服辅酶Q10（CoQ10）4周是否会提高其在健康、有体育锻炼习惯男性骨骼肌中的浓度，并影响其有氧运动能力（最大摄氧量）以及次最大运动期间的耗氧量。
6名平均年龄（±标准差）为29.7±7.2岁、最大摄氧量为39.4±8.5 mL·kg⁻¹·min⁻¹的志愿者参与了一项单盲试验。实验包括4个为期2周的阶段，顺序为安慰剂导入期、CoQ10补充期（每日150毫克）、CoQ10（150毫克）加维生素E（每日1000国际单位）期以及安慰剂洗脱期。在补充前及每个阶段结束时，进行了三阶段循环耐力测试（50、100和150瓦各持续4分钟），随后进行最大摄氧量测试（每分钟递增25瓦直至力竭）。在每次最大摄氧量测试前后采集血样，并在CoQ10补充4周前后从股外侧肌获取活检样本。
补充CoQ10后血浆CoQ10浓度显著升高（P<0.05），然而，每次运动测试前后其变化不显著（P>0.05）。肌肉CoQ10浓度、最大摄氧量通气阈值、运动耐力和氧亏在补充后均无显著变化。
据推测，在健康、非CoQ10缺乏男性中补充CoQ10无显著效果，可能是由于线粒体膜通常已被CoQ10饱和，或者所选的运动测试方案及变量不够敏感，无法检测到其效果。
