Fiebich B L, Lieb K, Berger M, Bauer J
Psychiatrische Klinik, Universität Freiburg, Germany.
J Neuroimmunol. 1995 Dec 31;63(2):207-11. doi: 10.1016/0165-5728(95)00145-x.
Interleukin-6 (IL-6) has previously been shown to participate in neurodegenerative processes including Alzheimer's disease. However, the mechanisms leading to increased IL-6 expression in the brain remain largely unknown. We have studied the effects of synthetic ceramides and sphingomyelinase as possible regulators of IL-6 gene expression in a human astrocytoma cell line. The synthetic ceramides C2- and C6-ceramide as well as the enzyme sphingomyelinase were able to induce IL-6 gene transcription and protein synthesis in a dose-dependent manner with maximal IL-6 mRNA levels being reached after 4 h of ceramide treatment. We propose that the sphingomyelin pathway is part of the signal transduction cascade leading to IL-6 gene expression in astrocytes, and that this pathway may be involved in IL-6-mediated neurodegenerative processes.
白细胞介素-6（IL-6）此前已被证明参与包括阿尔茨海默病在内的神经退行性过程。然而，导致大脑中IL-6表达增加的机制在很大程度上仍不清楚。我们研究了合成神经酰胺和鞘磷脂酶作为人星形细胞瘤细胞系中IL-6基因表达可能的调节因子的作用。合成神经酰胺C2-神经酰胺和C6-神经酰胺以及鞘磷脂酶能够以剂量依赖的方式诱导IL-6基因转录和蛋白质合成，在神经酰胺处理4小时后达到最大IL-6 mRNA水平。我们提出鞘磷脂途径是导致星形胶质细胞中IL-6基因表达的信号转导级联反应的一部分，并且该途径可能参与IL-6介导的神经退行性过程。
