Koretz R L, Camacho R
Dig Dis Sci. 1979 Jan;24(1):21-4. doi: 10.1007/BF01297233.
Emergency endoscopy was performed on two patients subsequently found to be hepatitis B surface antigen carriers. Before their carrier state was determined, nine other patients underwent endoscopy using the same instruments, which had been routinely cleaned between procedures. These patients were all notified within five days of the incident, given standard gamma globulin, and prospectively followed for the development of hepatitis. After one of the endoscopes was gas sterilized, the next three patients undergoing endoscopy were also followed. One of the hepatitis B surface antigen carriers was positive for antibody to e antigen; the other carrier had neither e antigen nor antibody. None of these individuals developed signs or symptoms of hepatitis, abnormal serum glutamic pyruvate transaminase elevations, or serologic evidence of hepatitis B exposure. From these data, and other recorded experiences, it appears that routine cleansing of endoscopy equipment is sufficient in preventing the transmission of hepatitis B.
随后对两名被发现为乙肝表面抗原携带者的患者进行了急诊内镜检查。在确定他们的携带者状态之前，另外九名患者使用相同的器械进行了内镜检查，这些器械在不同检查之间按常规进行了清洁。在事件发生后的五天内通知了所有这些患者，给予了标准的丙种球蛋白，并对他们进行前瞻性随访以观察肝炎的发生情况。其中一台内镜进行气体灭菌后，接下来接受内镜检查的三名患者也进行了随访。两名乙肝表面抗原携带者中，一名e抗原抗体呈阳性；另一名携带者既没有e抗原也没有抗体。这些个体均未出现肝炎的体征或症状、血清谷丙转氨酶异常升高或乙肝暴露的血清学证据。根据这些数据以及其他已记录的经验，看来内镜设备的常规清洁足以预防乙肝的传播。
