Mollica F, Musumeli S, Rugolo S, Mattina T
Arch Dis Child. 1979 Oct;54(10):750-4. doi: 10.1136/adc.54.10.750.
28 of 1002 pregnant Sicilian women (2.8%) were asymptomatic HBsAg chronic carriers. 18 children of these women were followed and at least 15 of them showed evidence of transplacental infection with HBsAg, resulting either from the presence of the antigen in cord blood, or from the development of the corresponding antibody in the serum within the first 2 months of life. Despite this, only 2 or 3 of the infants developed chronic antigenaemia from age 2--4 months. Only the infants whose mothers were HBeAb-negative, and who themselves remained HBsAb-negative during the first months of life, became HBsAg carriers. On the basis of these results, a strategy is suggested for selecting infants from areas with a high prevalence of HBsAg carriers so that they can be given passive immunisation with hyperimmune globulin.
1002名西西里岛孕妇中有28名（2.8%）是无症状HBsAg慢性携带者。对这些女性的18名子女进行了跟踪，其中至少15名显示有经胎盘感染HBsAg的证据，这是由于脐血中存在该抗原，或者是在出生后头2个月内血清中出现了相应抗体。尽管如此，只有2至3名婴儿在2至4个月大时出现慢性抗原血症。只有母亲HBeAb阴性且自身在出生后头几个月仍为HBsAb阴性的婴儿才会成为HBsAg携带者。基于这些结果，建议采取一种策略，从HBsAg携带者高流行地区挑选婴儿，以便为他们注射高效价免疫球蛋白进行被动免疫。
