瘙痒病病原体的免疫系统依赖性和非依赖性复制
Immune system-dependent and -independent replication of the scrapie agent.
作者信息
Lasmézas C I, Cesbron J Y, Deslys J P, Demaimay R, Adjou K T, Rioux R, Lemaire C, Locht C, Dormont D
机构信息
Service de Neurovirologie, Commissariat à l'Energie Atomique, DSV, DRM, CRSSA, Fontenay-aux-Roses, France.
出版信息
J Virol. 1996 Feb;70(2):1292-5. doi: 10.1128/JVI.70.2.1292-1295.1996.
Abstract
Using the severe combined immunodeficiency (SCID) mouse model, we investigated the requirement of the immune system for the development of scrapie after peripheral inoculation. A total of 33% of SCID mice, all but one immunologically reconstituted SCID mice (93%), and all CB17 control mice developed the disease. PrPres was detectable in the brains of all diseased animals and in the spleens of reconstituted SCID and CB17 control mice but not of the diseased non-immunologically reconstituted SCID mice. The immune system appears to be a primary target in the pathogenesis of scrapie, but direct spread to the central nervous system from the peritoneum via visceral nerve fibers can probably also occur.
摘要
利用严重联合免疫缺陷（SCID）小鼠模型，我们研究了外周接种后免疫系统对羊瘙痒病发生发展的需求。总共33%的SCID小鼠、除一只外的所有免疫重建SCID小鼠（93%）以及所有CB17对照小鼠都患上了该病。在所有患病动物的大脑以及免疫重建SCID小鼠和CB17对照小鼠的脾脏中均可检测到蛋白酶抗性朊蛋白（PrPres），但在未进行免疫重建的患病SCID小鼠脾脏中未检测到。免疫系统似乎是羊瘙痒病发病机制中的主要靶点，但朊病毒也可能通过内脏神经纤维从腹膜直接扩散至中枢神经系统。
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SCID mouse spleen does not support scrapie agent replication.重症联合免疫缺陷小鼠脾脏不支持羊瘙痒病病原体复制。
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