野生小家鼠（Mus castaneus）对多嗜性鼠白血病病毒抗性的遗传基础。
Genetic basis for resistance to polytropic murine leukemia viruses in the wild mouse species Mus castaneus.
作者信息
Lyu M S, Kozak C A
机构信息
Laboratory of Molecular Microbiology, National Institutes of Allergy and Infectious Diseases, NIH, Bethesda, MD 20892-0460, USA.
出版信息
J Virol. 1996 Feb;70(2):830-3. doi: 10.1128/JVI.70.2.830-833.1996.
Abstract
Cultured cells derived from the wild mouse species Mus castaneus were found to be uniquely resistant to exogenous infection by polytropic mink cell focus-forming (MCF) murine leukemia viruses (MuLVs). This MCF MuLV resistance is inherited as a genetically recessive trait in the progeny of F1 crosses between M. castaneus and MCF MuLV-susceptible laboratory mice. Examination of the progeny of backcrosses demonstrated that susceptibility is inherited as a single gene which maps to chromosome 1. The map location of this gene places it at or near the locus Rmc1, the gene encoding the receptor for MCF/xenotropic MuLVs, suggesting that resistance is mediated by the M. castaneus allele of this receptor.
摘要
研究发现，源自野生小鼠物种栗色小鼠（Mus castaneus）的培养细胞对多嗜性貂细胞集落形成（MCF）鼠白血病病毒（MuLVs）的外源感染具有独特的抗性。这种MCF MuLV抗性在栗色小鼠与MCF MuLV易感实验室小鼠的F1杂交后代中作为一种遗传隐性性状遗传。回交后代的检查表明，易感性作为一个单基因遗传，该基因定位于1号染色体。该基因的图谱位置表明它位于Rmc1基因座或其附近，Rmc1基因编码MCF/嗜异源性MuLVs的受体，这表明抗性是由该受体的栗色小鼠等位基因介导的。
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J Virol. 1993 Jul;67(7):4056-61. doi: 10.1128/JVI.67.7.4056-4061.1993.
2
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J Virol. 1994 Feb;68(2):626-31. doi: 10.1128/JVI.68.2.626-631.1994.
3
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Virology. 1982 Nov;123(1):139-51. doi: 10.1016/0042-6822(82)90301-4.
4
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