Kubota S, Tasaki T, Minami Y, Kanetake H, Saitoh Y
Department of Urology, Wajinkai Hospital, Japan.
Nihon Hinyokika Gakkai Zasshi. 1995 Nov;86(11):1610-5. doi: 10.5980/jpnjurol1989.86.1610.
The objective of this study is to evaluate the efficiency of a new method of transurethral balloon laser thermotherapy (TUBAL-T) using prostalase in patients with benign prostatic hyperplasia.
From September 1993 to March 1994, 21 men were treated with a single session of TUBAL-T for the relief of bladder outlet obstruction secondary to benign prostatic hyperplasia. Thirteen of them had hormonal therapy before TUBAL-T and have no mediation after treatment (group A). Eight men had no hormonal therapy before and after TUBAL-T (group B). The clinical efficacy of this modality was evaluated by analysing the subjective and objective responses following the treatment. The laser balloon, equipped with a cooling system for preservation of urethral mucosa, delivers a Nd:YAG laser into the prostate. Treatment was performed by using a laser powder of 30 to 50 watts for 40 minutes. At 3 months after treatment, the clinical efficacy was evaluated by subjective symptom score, and residual urine volume, uroflowmetry and prostatic volume by transrectal ultrasound as objective data.
In group A, subjective symptom scores decreased by an average of 72.8%, the average uroflow rates and the peak uroflow rates increased by an average of 44% and 45.9%, the post-void residual urine volume rates decreased by an average of 58.4% and ultrasonography showed that the prostatic volume decreased in 8 men but increased in 5 men. In group B, symptom score decreased by an average of 85.1%, the average uroflow rates and the peak uroflow rates increased by an average of 46.2%, the post-void residual urine volume rates decreased by average of 83.4% and ultrasonography showed that the prostatic volume decreased by an average of 35.6%.
During the treatment and follow-up period, no adverse effect was detected. These results suggest that TUBAL-T for the relief of bladder outlet obstruction secondary to BPH is a useful therapy.
本研究的目的是评估一种使用前列腺酶的经尿道球囊激光热疗(TUBAL-T)新方法对良性前列腺增生患者的疗效。
1993年9月至1994年3月,21名男性接受了单次TUBAL-T治疗,以缓解良性前列腺增生引起的膀胱出口梗阻。其中13人在TUBAL-T治疗前接受过激素治疗,治疗后无需药物治疗(A组)。8名男性在TUBAL-T治疗前后均未接受激素治疗(B组)。通过分析治疗后的主观和客观反应来评估这种治疗方式的临床疗效。配备有用于保护尿道黏膜的冷却系统的激光球囊,将钕:钇铝石榴石激光输送到前列腺。使用30至50瓦的激光功率进行40分钟的治疗。治疗后3个月,通过主观症状评分评估临床疗效,并以经直肠超声测量残余尿量、尿流率和前列腺体积作为客观数据。
A组中,主观症状评分平均下降72.8%,平均尿流率和最大尿流率平均分别增加44%和45.9%,排尿后残余尿量平均下降58.4%,超声检查显示8名男性前列腺体积减小,5名男性前列腺体积增大。B组中,症状评分平均下降85.1%,平均尿流率和最大尿流率平均分别增加46.2%,排尿后残余尿量平均下降83.4%,超声检查显示前列腺体积平均减小35.6%。
在治疗和随访期间,未检测到不良反应。这些结果表明,TUBAL-T用于缓解良性前列腺增生引起的膀胱出口梗阻是一种有效的治疗方法。