Alasti H, Galbraith D M
Princess Margaret Hospital, Toronto, Ontario, Canada.
Med Phys. 1995 Oct;22(10):1675-83. doi: 10.1118/1.597432.
A common problem with low-energy electron beams (< 15 MeV) is their low surface dose when the incident electrons are monodirectional. This makes it difficult to deliver a uniform dose to tumor with any precision, limiting the clinical usefulness of such beams. A practical method is presented for greatly increasing the tissue depth enclosed by the 95% isodose region, while delivering the entire dose in a single uninterrupted treatment. Beam modification is achieved by placing a wire mesh of high atomic number (Z) on the treatment surface throughout the treatment. Electron beams of energies 6, 9, and 13 MeV are modified to produce a near uniform dose from the surface to the original depth of maximum, approximately doubling the depth enclosed by the 95% isodose. These beams have a step-function-like depth dose and can be arranged to deliver a constant dose to tumor located at varying depths while simultaneously sparing deeper tissues which are also located at varying depths. A single mesh design was found to be suitable for all energies.
低能量电子束(<15 MeV)的一个常见问题是,当入射电子为单向时,其表面剂量较低。这使得难以精确地向肿瘤输送均匀剂量,限制了此类电子束的临床应用价值。本文提出了一种实用方法,可在单次不间断治疗中输送全部剂量的同时,大幅增加95%等剂量区域所覆盖的组织深度。通过在整个治疗过程中将高原子序数(Z)的金属丝网放置在治疗表面来实现束流修正。对能量为6、9和13 MeV的电子束进行修正,以产生从表面到原始最大深度处近乎均匀的剂量,使95%等剂量区域所覆盖的深度增加约一倍。这些电子束具有类似阶梯函数的深度剂量分布,可设置为向位于不同深度的肿瘤输送恒定剂量,同时使同样位于不同深度的深部组织免受照射。研究发现单一的丝网设计适用于所有能量。