Suppr超能文献

使用金属丝网敷贴器实现电子束深度剂量平坦化。

Depth dose flattening of electron beams using a wire mesh bolus.

作者信息

Alasti H, Galbraith D M

机构信息

Princess Margaret Hospital, Toronto, Ontario, Canada.

出版信息

Med Phys. 1995 Oct;22(10):1675-83. doi: 10.1118/1.597432.

Abstract

A common problem with low-energy electron beams (< 15 MeV) is their low surface dose when the incident electrons are monodirectional. This makes it difficult to deliver a uniform dose to tumor with any precision, limiting the clinical usefulness of such beams. A practical method is presented for greatly increasing the tissue depth enclosed by the 95% isodose region, while delivering the entire dose in a single uninterrupted treatment. Beam modification is achieved by placing a wire mesh of high atomic number (Z) on the treatment surface throughout the treatment. Electron beams of energies 6, 9, and 13 MeV are modified to produce a near uniform dose from the surface to the original depth of maximum, approximately doubling the depth enclosed by the 95% isodose. These beams have a step-function-like depth dose and can be arranged to deliver a constant dose to tumor located at varying depths while simultaneously sparing deeper tissues which are also located at varying depths. A single mesh design was found to be suitable for all energies.

摘要

低能量电子束(<15 MeV)的一个常见问题是,当入射电子为单向时,其表面剂量较低。这使得难以精确地向肿瘤输送均匀剂量,限制了此类电子束的临床应用价值。本文提出了一种实用方法,可在单次不间断治疗中输送全部剂量的同时,大幅增加95%等剂量区域所覆盖的组织深度。通过在整个治疗过程中将高原子序数(Z)的金属丝网放置在治疗表面来实现束流修正。对能量为6、9和13 MeV的电子束进行修正,以产生从表面到原始最大深度处近乎均匀的剂量,使95%等剂量区域所覆盖的深度增加约一倍。这些电子束具有类似阶梯函数的深度剂量分布,可设置为向位于不同深度的肿瘤输送恒定剂量,同时使同样位于不同深度的深部组织免受照射。研究发现单一的丝网设计适用于所有能量。

文献检索

告别复杂PubMed语法,用中文像聊天一样搜索,搜遍4000万医学文献。AI智能推荐,让科研检索更轻松。

立即免费搜索

文件翻译

保留排版,准确专业,支持PDF/Word/PPT等文件格式,支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述,25分钟生成高质量综述,智能提取关键信息,辅助科研写作。

立即免费体验