Van der Kamp W, Rothwell J C, Thompson P D, Day B L, Marsden C D
Medical Research Council, Institute of Neurology, London, England.
Mov Disord. 1995 Sep;10(5):630-3. doi: 10.1002/mds.870100516.
Voluntary movements, such as the self-paced finger extension task used in the present experiments, are preceded by a slowly rising negative electroencephalographic potential [the movement-related cortical potential (MRCP)]. The early NS1 component of the potential was no different in patients with primary dystonia affecting the arm (n = 6) compared with matched controls. In contrast, the peak amplitude of the MRCP was smaller in the patients, despite the fact that the movements made by the two groups were very similar; it was of equal size over both left and right hemispheres, rather than being larger on the side contralateral to the movement. These results are similar to those observed by others in patients with symptomatic dystonia secondary to lesions of the basal ganglia or their output pathways and may reflect abnormal basal ganglia input to motor areas of cortex before the onset of a self-paced movement.
诸如本实验中使用的自定节奏手指伸展任务等自主运动之前，会出现一种缓慢上升的负性脑电图电位[运动相关皮层电位（MRCP）]。与匹配的对照组相比，影响手臂的原发性肌张力障碍患者（n = 6）的该电位早期NS1成分并无差异。相比之下，尽管两组的动作非常相似，但患者的MRCP峰值幅度较小；该电位在左右半球大小相等，而非在与动作对侧的半球更大。这些结果与其他在基底神经节或其输出通路病变继发的症状性肌张力障碍患者中观察到的结果相似，可能反映了在自定节奏运动开始前，基底神经节对皮层运动区域的异常输入。
