Stewart L A, Clarke M J
MRC Cancer Trials Office, Cambridge, U.K.
Stat Med. 1995 Oct 15;14(19):2057-79. doi: 10.1002/sim.4780141902.
Meta-analyses using updated individual patient data may provide the most reliable means of combining data from similar randomized controlled trials. The benefits of this approach to systematic reviews are described. Guidance, based on the experience of several groups who have undertaken such projects, is given. This includes practical advice on initiating and maintaining collaboration, the time and resources required to undertake these usually international projects and methods of data checking and validation. Example proforma are included.
使用更新后的个体患者数据进行的荟萃分析可能提供整合来自相似随机对照试验数据的最可靠方法。描述了这种方法对系统评价的益处。基于多个开展此类项目的团队的经验给出了指导意见。这包括关于启动和维持合作的实用建议、开展这些通常为国际性项目所需的时间和资源，以及数据检查和验证方法。文中包含示例表格。
