Khavinson V Kh, Morozov V G, Chalisova N I, Okulov V B
Institute of Bioregulation and Gerontology, St. Petersburg.
Tsitologiia. 1997;39(7):571-6.
The effect of cortexin and epithalamin on the cell growth rate was investigated in the organotypic tissue culture of dorsal root ganglia (DRG), and of cortex and subcortical structures of 10-11-day old chick embryos. Cortexin in concentrations of 20 and 100 ng/ml is active, inducing a more intensive neurite outgrowth in DRG, compared to the control. Epithalamin was active in concentrations 20 and 200 ng/ml. Cortexin (100 ng/ml) was active in the cortex tissue culture, but inhibited the neurite growth in the subcortical structures culture. The stimulation of this culture to development was evident after using 200 ng/ml epithalamin. The neurite stimulating effect of cortexin and epithalamin is presumably associated with neurotrophic factors.
研究了皮质激素和表胚素对背根神经节（DRG）以及10 - 11日龄鸡胚皮质和皮质下结构的器官型组织培养中细胞生长速率的影响。浓度为20和100 ng/ml的皮质激素具有活性，与对照组相比，能诱导DRG中更密集的神经突生长。表胚素在浓度为20和200 ng/ml时具有活性。皮质激素（100 ng/ml）在皮质组织培养中具有活性，但在皮质下结构培养中抑制神经突生长。使用200 ng/ml表胚素后，该培养物的发育刺激作用明显。皮质激素和表胚素的神经突刺激作用可能与神经营养因子有关。
