[神经生长因子在神经组织培养物暴露于白喉毒素时的保护作用]
[The protective effect of the nerve growth factor in exposing a nerve tissue culture to diphtheria toxin].
作者信息
Chalisova N I, Akoev G N, Penniiaĭnen V A
机构信息
Pavlov Institute of Physiology, RAS, St. Petersburg.
出版信息
Morfologiia. 1998;114(4):41-4.
PMID:9826817
Abstract
Diphtheria toxin (1.10(-1)-1.10(-6) Lf/ml) was found to inhibit neurite extension in chick embryo dorsal root ganglia in vitro. If the nerve growth factor (60 ng/ml) was added with toxin in culture media the diphtheria toxin effect was decreased and the neurite outgrowth was compared with control. Protective effect of nerve growth factor by influence of diphtheria toxin may be used in new principles of diphtheria treatment.
摘要
发现白喉毒素（1.10⁻¹ - 1.10⁻⁶Lf/ml）在体外可抑制鸡胚背根神经节中的神经突延伸。如果在培养基中加入神经生长因子（60 ng/ml）和毒素，白喉毒素的作用会减弱，神经突生长情况与对照组进行比较。神经生长因子对白喉毒素影响的保护作用可用于白喉治疗的新原则。
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