Trojniar W, Staszewska M
Department of Animal Physiology, University of Gdańsk, Poland.
Acta Neurobiol Exp (Wars). 1995;55(3):201-6. doi: 10.55782/ane-1995-1076.
The pedunculopontine tegmental nucleus (PPN) is anatomically connected with dopaminergic cells in the ventral mesencephalon, which are known to participate in the regulation of various adaptive appetitive behaviours. In the present experiment we studied a possible involvement of PPN in feeding elicited by stimulation of the ventral tegmental area (VTA). It was found that bilateral electrolytic lesioning of the PPN affected VTA-elicited feeding. However, the effects were diverse and showed dependence on the localization of the lesion within the PPN area. Lesions localized anteriorly in the PPN impaired VTA feeding whereas those involving the middle portion of the nucleus facilitated electrically elicited food ingestion. A precise alignment of the lesion and the area activated at the site of stimulation appeared crucial for the effect of the lesion. The results indicate that PPN belongs to the central feeding circuitry and it contains both activating and inhibiting elements directed to the ventral tegmental area.
脚桥被盖核（PPN）在解剖学上与中脑腹侧的多巴胺能细胞相连，已知这些多巴胺能细胞参与各种适应性食欲行为的调节。在本实验中，我们研究了PPN在腹侧被盖区（VTA）刺激诱发的进食中可能发挥的作用。结果发现，PPN的双侧电解损伤影响了VTA诱发的进食。然而，这些影响是多样的，并且显示出依赖于损伤在PPN区域内的定位。位于PPN前部的损伤会损害VTA诱发的进食，而涉及该核中部的损伤则会促进电刺激诱发的食物摄取。损伤与刺激部位激活区域的精确对齐似乎对损伤的效果至关重要。结果表明，PPN属于中枢进食回路，并且它包含针对腹侧被盖区的激活和抑制元件。
