[慢性恰加斯病中的冠状动脉粥样硬化与心肌梗死]
[Coronary arteriosclerosis and myocardial infarction in chronic Chagas' disease].
作者信息
Lopes E R, de Mesquita P M, de Mesquita L F, Chapadeiro E
机构信息
Faculdade de Medicina do Triângulo Mineiro, Uberaba, MG.
出版信息
Arq Bras Cardiol. 1995 Aug;65(2):143-5.
PURPOSE
To evaluate both the frequency of myocardial infarction and coronary atherosclerosis as well as the pathology of the later in necropsied chronic chagasic individuals.
METHODS
Systematized gross and light microscopy were performed in hearts, especially at the three main coronary arteries. Eighty-nine hearts were studied, 35 chronic chagasics and 54 nonchagasics, all from males. Statistical tests were used for frequency analysis.
RESULTS
Myocardial infarction occurred in 8.6% chagasics and in 7.4% nonchagasics. Coronary atherosclerosis was detected in 71.4% of chagasics and in 74.1% of nonchagasics. Its morphology was similar for both groups and indistinguishable from the classical descriptions of atherosclerosis. There were no cases showing lesions compatible with accelerated coronary atherosclerosis.
CONCLUSION
The frequency of myocardial infarction and coronary atherosclerosis was the same for both chagasics and nonchagasic individuals. The morphological findings for the studied arteriopathy were identical for the two considered groups. However, it seems that the frequency of myocardial infarction is higher in chagasics with normal coronary arteries (with or without minimal atherosclerotic lesions), as compared with nonchagasics.
目的
评估尸检的慢性恰加斯病患者中心肌梗死和冠状动脉粥样硬化的发生率以及后者的病理情况。
方法
对心脏进行系统的大体和光学显微镜检查，尤其针对三条主要冠状动脉。共研究了89颗心脏，其中35颗来自慢性恰加斯病患者，54颗来自非恰加斯病患者，均为男性。采用统计学检验进行频率分析。
结果
恰加斯病患者中心肌梗死发生率为8.6%，非恰加斯病患者中为7.4%。恰加斯病患者中冠状动脉粥样硬化检出率为71.4%，非恰加斯病患者中为74.1%。两组的粥样硬化形态相似，与动脉粥样硬化的经典描述无异。未发现与加速性冠状动脉粥样硬化相符的病变病例。
结论
恰加斯病患者和非恰加斯病患者中心肌梗死和冠状动脉粥样硬化的发生率相同。所研究的动脉病变的形态学表现，在两组中是一致的。然而，与非恰加斯病患者相比，冠状动脉正常（有或无轻度粥样硬化病变）的恰加斯病患者中心肌梗死的发生率似乎更高。
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