Bekpinar S, Tugrul Y
Department of Biochemistry, Istanbul Medical Faculty, University of Istanbul, Turkey.
Alcohol Alcohol. 1995 Sep;30(5):645-50.
Prolonged consumption of alcohol leads to peroxidative damage in testicular tissues and gonadal dysfunction. Selenium (Se) deficiency also gives rise to testicular structural and functional disturbances similar to those caused by alcohol. We examined the possibility that Se supplementation might, at least partially, prevent the testicular disorders induced by alcohol. Rats were fed alcohol and alcohol with 3 p.p.m. Se in drinking water for 5 months. Ethanol administration decreased vitamin C and glutathione levels in testicular tissue, but caused no alterations in vitamin E and polyunsaturated fatty acid levels. However, lipid peroxide levels were increased by alcohol. Selenium supplementation diminished both the depletion of vitamin C and the production of lipid peroxides, but did not affect the depletion of glutathione induced by alcohol in testicular tissue. In addition, Se supplementation ameliorated the decrement of serum testosterone levels induced by alcohol.
长期饮酒会导致睾丸组织的过氧化损伤和性腺功能障碍。硒（Se）缺乏也会引起与酒精所致类似的睾丸结构和功能紊乱。我们研究了补充硒至少部分预防酒精所致睾丸疾病的可能性。给大鼠喂食酒精以及含百万分之三硒的酒精溶液5个月。给予乙醇降低了睾丸组织中维生素C和谷胱甘肽水平，但未改变维生素E和多不饱和脂肪酸水平。然而，酒精会使脂质过氧化物水平升高。补充硒减少了维生素C的消耗和脂质过氧化物的产生，但不影响酒精所致睾丸组织中谷胱甘肽的消耗。此外，补充硒改善了酒精所致血清睾酮水平的降低。
