Fäh J, Wüthrich B, Vieths S
Department of Dermatology University Hospital, Zürich, Switzerland.
Clin Exp Allergy. 1995 Oct;25(10):1018-23. doi: 10.1111/j.1365-2222.1995.tb00405.x.
Due to the increasing popularity of exotic fruits in the Western diet, allergologists are confronted with allergic reactions to substances in these plants. The present report describes an anaphylactic reaction after the consumption of lychee fruit (Litchi sinensis). The atopic patient also suffers from rhinoconjunctivitis due to a sensitization against pollen of the Compositae family, as well as from dyspnoea after eating sunflower seeds. Our goals were to determine crossreactivity between antibodies against lychee fruit and other plants and to characterize the allergen.
Specific IgE against lychee fruits were detected by an EAST assay. The allergen was characterized by immunoblot, immunoblot inhibition and EAST inhibition assays. Broad crossreactivity between lychee fruit and other plants was found and profilin identified as the protein responsible for the patient's complex allergy syndrome.
Lychee fruit contains a significant amount of profilin. Consumption of this exotic fruit can cause severe anaphylactic reactions in patients being sensitized against the plant pan-allergen profilin.
由于异国水果在西方饮食中越来越受欢迎，过敏症专科医生面临着这些植物中物质引起的过敏反应。本报告描述了食用荔枝（Litchi sinensis）后发生的过敏反应。这位特应性患者还因对菊科花粉过敏而患有鼻结膜炎，并且食用向日葵籽后会出现呼吸困难。我们的目标是确定针对荔枝果实的抗体与其他植物之间的交叉反应性，并对过敏原进行表征。
通过EAST试验检测针对荔枝果实的特异性IgE。通过免疫印迹、免疫印迹抑制和EAST抑制试验对过敏原进行表征。发现荔枝果实与其他植物之间存在广泛的交叉反应性，并鉴定出肌动蛋白结合蛋白是导致患者复杂过敏综合征的蛋白质。
荔枝果实含有大量肌动蛋白结合蛋白。食用这种异国水果会使对植物泛过敏原肌动蛋白结合蛋白致敏的患者发生严重的过敏反应。
