Nucera Eleonora, Mezzacappa Simona, Aruanno Arianna, Pecora Valentina, Rizzi Angela, Ricci Anna Giulia, Ferraironi Manuela, Buonomo Alessandro, Schiavino Domenico
Allergy Unit, Università Cattolica del Sacro Cuore - Policlinico "A. Gemelli", Rome, Italy. Head of the Unit: Domenico Schiavino.
Postepy Dermatol Alergol. 2015 Aug;32(4):255-61. doi: 10.5114/pdia.2015.53321. Epub 2015 Aug 12.
Lipid transfer proteins (LTP), profilin and PR-10 are the most important panallergens in central and southern Italy. Lipid transfer proteins are stable molecules, predominantly present in the fruit peel, which can induce systemic symptoms after ingestion of vegetables. Profilin and PR-10 are randomly distributed in the pulp and peel. Both are labile proteins and usually determine reactions restricted to the oral cavity. Panallergens-specific IgE may cross-react with homologues from different plant sources, due to their conserved structure.
To assess the pattern of sensitization to panallergens and the correlation with the clinical history and the allergological evaluation of food and aeroallergens.
One hundred and twenty patients with adverse reactions after vegetables ingestion underwent skin prick tests (SPT) with commercial extracts of plant-derived foods and inhalant allergens and commercial extracts of LTP, profilin and PR-10.
Many patients presented positive SPT with different plant-food allergens. We found that 76 patients were sensitized to LTP, 14 to profilin and 5 to PR-10. In the LTP-sensitized group, 64 (84%) patients suffered from systemic symptoms while the patients sensitized only to profilin referred the oral allergy syndrome.
This study shows a high rate of sensitization to LTP in our population according to the literature about food allergy in our geographical area and confirms the literature data about the symptoms referred by patients with sensitization to panallergens. Panallergens should be considered as clinically relevant food allergens.
脂质转移蛋白（LTP）、肌动蛋白结合蛋白和病程相关蛋白10是意大利中部和南部最重要的泛过敏原。脂质转移蛋白是稳定的分子，主要存在于果皮中，摄入蔬菜后可诱发全身症状。肌动蛋白结合蛋白和病程相关蛋白10随机分布于果肉和果皮中。两者都是不稳定的蛋白质，通常只会引发口腔局部反应。由于结构保守，泛过敏原特异性IgE可能会与不同植物来源的同源物发生交叉反应。
评估对泛过敏原的致敏模式以及与临床病史、食物和吸入性过敏原的变应性评估之间的相关性。
120例蔬菜摄入后出现不良反应的患者接受了皮肤点刺试验（SPT），使用植物源性食品和吸入性过敏原的商业提取物以及脂质转移蛋白、肌动蛋白结合蛋白和病程相关蛋白10的商业提取物。
许多患者对不同的植物性食物过敏原皮肤点刺试验呈阳性。我们发现76例患者对脂质转移蛋白致敏，14例对肌动蛋白结合蛋白致敏，5例对病程相关蛋白10致敏。在脂质转移蛋白致敏组中，64例（84%）患者出现全身症状，而仅对肌动蛋白结合蛋白致敏的患者出现口腔过敏综合征。
根据我们地理区域关于食物过敏的文献，本研究显示我们的人群中对脂质转移蛋白的致敏率很高，并证实了关于泛过敏原致敏患者所报告症状的文献数据。泛过敏原应被视为具有临床相关性的食物过敏原。
