Amantadine does not reduce cocaine use or craving in cocaine-dependent methadone maintenance patients.
作者信息
Handelsman L, Limpitlaw L, Williams D, Schmeidler J, Paris P, Stimmel B
机构信息
Department of Psychiatry, Mount Sinai Medical Center, New York, NY 10029, USA.
出版信息
Drug Alcohol Depend. 1995 Oct;39(3):173-80. doi: 10.1016/0376-8716(95)01154-9.
PMID:8556965
Abstract
We tested the efficacy of amantadine to reduce cocaine use or craving in cocaine-dependent methadone maintained patients. Two doses of amantadine (200 mg p.o. daily, n = 16, and 200 mg p.o. bid, n = 21) were tested against placebo, n = 22, in a random assignment, double-blind clinical trial lasting nine weeks. Amantadine was well tolerated. However, neither dose of amantadine was more effective than placebo in reducing cocaine use and craving.
摘要
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