Monk T H, Buysse D J, Reynolds C F, Kupfer D J, Houck P R
Sleep and Chronobiology Center, Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, PA 15213, USA.
Exp Gerontol. 1995 Sep-Oct;30(5):455-74. doi: 10.1016/0531-5565(95)00007-4.
This collection of studies had the aim of exploring whether older (77+ years) men and women have circadian body temperature rhythms different from those of younger adults. A total of 20 older men and 28 older women were compared with either 22 young men or 14 middle-aged men in four protocols; all but the first protocol using a subset of the sample. The four protocols were: 1) 24 h, and 2) 72 h data collections on a normal laboratory routine (sleeping at night); 3) between 36 h and 153 h of field data collection at home; and 4) 36 h of a constant conditions routine (wakeful bedrest under temporal isolation) in the laboratory. There was some evidence for an age-related phase advance in temperature rhythm, especially for the older men on a normal routine, though this was not present in the constant conditions protocol, where 5 of the older subjects showed major delays in the timing of the body temperature trough (10:00 or later). There was no statistically significant evidence from any of the protocols that older subjects generally had lower temperature rhythm amplitudes than younger adults. Only when older men were compared with younger men in 24-h rhythm amplitude by simple t-test did any comparison involving amplitude achieve statistical significance (p < 0.05).
这项研究集合旨在探究77岁及以上的老年男性和女性的昼夜体温节律是否与年轻人不同。在四个方案中，将总共20名老年男性和28名老年女性与22名年轻男性或14名中年男性进行了比较；除第一个方案外，其他方案均使用了部分样本。这四个方案分别是：1）24小时，以及2）按照正常实验室日常安排（夜间睡眠）进行72小时的数据收集；3）在家进行36小时至153小时的实地数据收集；4）在实验室进行36小时的恒定条件日常安排（在时间隔离下清醒卧床休息）。有一些证据表明体温节律存在与年龄相关的相位提前，特别是对于按照正常日常安排的老年男性而言，不过在恒定条件方案中并未出现这种情况，在该方案中，5名老年受试者的体温低谷时间出现了严重延迟（10:00或更晚）。在任何一个方案中，均没有统计学上显著的证据表明老年受试者的体温节律幅度总体上低于年轻人。只有在通过简单t检验比较老年男性与年轻男性在24小时节律幅度时，涉及幅度的任何比较才达到统计学显著性（p < 0.05）。
