在相同环境条件下近交系和远交系大鼠寿命的品系内和品系间变异性。
Within- and between-strain variability in longevity of inbred and outbred rats under the same environmental conditions.
作者信息
Ghirardi O, Cozzolino R, Guaraldi D, Giuliani A
机构信息
Institute for Research on Senescence, Sigma-Tau S.p.A., Pomezia, Roma, Italy.
出版信息
Exp Gerontol. 1995 Sep-Oct;30(5):485-94. doi: 10.1016/0531-5565(95)00002-x.
Abstract
The analysis of 26 longevity curves of different populations of inbred (Fischer 344) and outbred (Sprague-Dawley) rats highlighted a remarkable between-populations variability in survival parameters. This variability is independent of the breeding characteristics of the strain. The two strains differed in the slope of the survival curves, with Fischer 344 rats showing a higher survival over the second year of life as well as a lower interindividual variability. A model-free approach based on principal component analysis allowed us to quantify these differences and to high-light some limitations of the classical Gompertzian approach.
摘要
对近交系（Fischer 344）和远交系（Sprague-Dawley）大鼠不同种群的26条寿命曲线进行分析后发现，各群体在生存参数方面存在显著差异。这种差异与品系的繁殖特性无关。两个品系在生存曲线的斜率上存在差异，Fischer 344大鼠在生命的第二年显示出更高的生存率以及更低的个体间变异性。基于主成分分析的无模型方法使我们能够量化这些差异，并突出经典Gompertzian方法的一些局限性。
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