人尿激酶受体基因（PLAUR）第3内含子中的一个高度多态性的CA/GT重复序列。
A highly polymorphic CA/GT repeat in intron 3 of the human urokinase receptor gene (PLAUR).
作者信息
Kohonen-Corish M R, Wang Y, Doe W F
机构信息
Division of Clinical Sciences, John Curtin School of Medical Research, Australian National University, Canberra, Australia.
出版信息
Hum Genet. 1996 Jan;97(1):124-5. doi: 10.1007/BF00218847.
We describe the first highly polymorphic microsatellite marker for the human urokinase plasminogen activator receptor gene (PLAUR). The urokinase receptor (uPAR) has a central role in cancer invasion and metastasis, which may enable the development of new anti-metastatic therapies. Analysis of the marker genotypes in colorectal cancer cell lines revealed three alleles that were not detected in a series of healthy control individuals, which encourages further genetic study of the role of uPAR in cancer.
我们描述了首个针对人尿激酶型纤溶酶原激活物受体基因（PLAUR）的高度多态性微卫星标记。尿激酶受体（uPAR）在癌症侵袭和转移中起核心作用，这可能有助于开发新的抗转移疗法。对结肠癌细胞系中该标记基因型的分析揭示了在一系列健康对照个体中未检测到的三个等位基因，这鼓励对uPAR在癌症中的作用进行进一步的遗传学研究。
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