由CCL1基因编码的酵母RNA聚合酶II转录因子TFIIH的亚基。
Subunits of yeast RNA polymerase II transcription factor TFIIH encoded by the CCL1 gene.
作者信息
Svejstrup J Q, Feaver W J, Kornberg R D
机构信息
Department of Structural Biology, Stanford University School of Medicine, California 94305-5400, USA.
出版信息
J Biol Chem. 1996 Jan 12;271(2):643-5. doi: 10.1074/jbc.271.2.643.
PMID:8557668
Abstract
Both 45- and 47-kDa subunits of TFIIK, a subcomplex of RNA polymerase II general transcription factor TFIIH, are encoded by the yeast cyclin gene CCL1. In all likelihood, these two subunits individually form cyclin-dependent kinase/cyclin dimers with Kin28 protein, a key enzyme in phosphorylation of the C-terminal domain of RNA polymerase II concomitant with transcription.
摘要
RNA聚合酶II通用转录因子TFIIH的一个亚复合物TFIIK的45 kDa和47 kDa亚基均由酵母细胞周期蛋白基因CCL1编码。很有可能，这两个亚基分别与Kin28蛋白形成细胞周期蛋白依赖性激酶/细胞周期蛋白二聚体，Kin28蛋白是RNA聚合酶II C端结构域在转录过程中磷酸化的关键酶。
Zotero 插件