Jacobson L S, Kirberger R M, Nesbit J W
Department of Medicine, Faculty of Veterinary Science, University of Pretoria, Onderstepoort, South Africa.
J Vet Intern Med. 1995 Nov-Dec;9(6):399-404. doi: 10.1111/j.1939-1676.1995.tb03300.x.
In dogs, hepatocutaneous syndrome (superficial necrolytic dermatitis) belongs to a group of syndromes in which cutaneous signs signal the presence of systemic disease. It is characterized by parakeratosis, superficial necrolysis, and basilar hyperplasia of the epidermis, in association with an unusual hepatopathy accompanied by certain metabolic derangements. Hepatocutaneous syndrome was diagnosed in 3 dogs on the basis of typical dermatologic changes and clinicopathologic findings. Hepatic ultrasonography revealed a hyperechoic network surrounding hypoechoic areas of parenchyma, resulting in a Swiss cheese-like appearance. The ultrasonographic image corresponded to the pathological findings. The liver had a nodular appearance, both grossly and microscopically; this was attributed to collapse of the areas of parenchyma surrounding the nodules, rather than to the cirrhosis and/or nodular hyperplasia reported previously.
在犬类中，肝皮肤综合征（浅表性坏死性皮炎）属于一组综合征，其中皮肤症状提示存在全身性疾病。其特征为角化不全、浅表性坏死溶解以及表皮基底增生，并伴有一种特殊的肝病及某些代谢紊乱。根据典型的皮肤病学变化和临床病理检查结果，3只犬被诊断为肝皮肤综合征。肝脏超声检查显示，实质低回声区周围有高回声网络，呈现出瑞士奶酪样外观。超声图像与病理检查结果相符。肝脏在大体和显微镜下均呈结节状外观；这归因于结节周围实质区域的塌陷，而非先前报道的肝硬化和/或结节性增生。
