Windebank A J, Litchy W J, Daube J R, Iverson R A
Department of Neurology, Mayo Clinic, Rochester, MN 55905, USA.
Neurology. 1996 Jan;46(1):80-4. doi: 10.1212/wnl.46.1.80.
We completed a prospective, population-based cohort study of polio survivors in Olmsted County, Minnesota, between 1986 and 1993. We identified 50 individuals who had had paralytic polio between 1935 and 1960, as representative of all 300 cases of paralytic polio in the county. We completed detailed quantitative clinical and electrophysiologic studies at entry and after 5 years. These studies demonstrated stable neuromuscular function within the cohort, although 60% of the individuals were symptomatic. In two-thirds of the symptomatic patients, the causes of their symptoms were unrelated to earlier polio. For the 20% of patients who had unexplained muscle pain, perception of weakness, and fatigue, a mechanical disorder most likely underlies their symptoms.
1986年至1993年间，我们在明尼苏达州奥尔姆斯特德县完成了一项针对脊髓灰质炎幸存者的前瞻性、基于人群的队列研究。我们确定了50名在1935年至1960年间患过麻痹性脊髓灰质炎的个体，作为该县所有300例麻痹性脊髓灰质炎病例的代表。我们在入组时和5年后完成了详细的定量临床和电生理研究。这些研究表明，队列中的神经肌肉功能稳定，尽管60%的个体有症状。在三分之二有症状的患者中，其症状原因与早期脊髓灰质炎无关。对于20%有无法解释的肌肉疼痛、无力感和疲劳感的患者，其症状很可能是由机械性疾病引起的。
