Windebank A J, Litchy W J, Daube J R, Kurland L T, Codd M B, Iverson R
Department of Neurology, Mayo Clinic, Rochester, MN 55905.
Neurology. 1991 Apr;41(4):501-7. doi: 10.1212/wnl.41.4.501.
We identified a cohort of 300 individuals who had paralytic polio between 1935 and 1955. All lived in Olmsted County, Minnesota. From the 247 survivors, we selected 50 subjects for detailed historical, functional, psychological, clinical, and electrophysiologic evaluation. Sixty-four percent of these 50 survivors complained of new symptoms of muscle pain, fatigue, and weakness after a period of prolonged stability. This led to changes in lifestyle or activity in only 18%. The likelihood of expressing new complaints was not related to present age or interval since polio, and electrophysiologic testing did not distinguish between those with or without new problems. The development of new difficulties in a limb was most strongly predicted by significant paralysis of that limb at the time of the acute illness. Patients with leg weakness were twice as likely to complain of new problems compared to those with arm weakness. Elevated creatine kinase levels were present only in those with new complaints.
我们确定了一组在1935年至1955年间患麻痹性脊髓灰质炎的300人。他们都生活在明尼苏达州的奥尔姆斯特德县。在247名幸存者中，我们挑选了50名受试者进行详细的病史、功能、心理、临床和电生理评估。在这50名幸存者中，64%的人在经历了一段长时间的病情稳定期后，出现了肌肉疼痛、疲劳和无力等新症状。但只有18%的人因此改变了生活方式或活动。出现新症状的可能性与当前年龄或患脊髓灰质炎后的时间间隔无关，电生理测试也无法区分有新问题和没有新问题的人。急性疾病发作时该肢体严重瘫痪最能有力地预测肢体出现新的问题。腿部无力的患者出现新问题的可能性是手臂无力患者的两倍。肌酸激酶水平升高仅出现在有新症状的患者中。
