Trenkwalder C, Stiasny K, Pollmächer T, Wetter T, Schwarz J, Kohnen R, Kazenwadel J, Krüger H P, Ramm S, Künzel M
Department of Neurology, University of Munich, Klinikum Grosshadern, Germany.
Sleep. 1995 Oct;18(8):681-8. doi: 10.1093/sleep/18.8.681.
We report the effects of a single bedtime dose of L-dopa 100-200 mg on sleep quality, frequency of periodic leg movements (PLM) and daily living in patients with idiopathic and uremic restless legs syndrome (RLS). Seventeen patients with idiopathic and 11 with uremic (on continuous hemodialysis) RLS were evaluated comparatively by polysomnography, actigraphy and subjective ratings in a randomized, controlled and double-blind crossover trial with L-dopa and placebo for 4 weeks each. Neurophysiologic assessments showed significant reduction of the number of periodic leg movements (p = 0.003) and the PLM-index (p = 0.005) most pronounced during the first 4 hours of bedtime after L-dopa (p = 0.001). Subjective evaluation confirmed improvement of sleep quality (p = 0.002) and showed significantly higher quality of life during daytime (p = 0.030) while the patients received L-dopa therapy. We conclude that L-dopa 100-200 mg proved to be effective in idiopathic RLS and for the first time under controlled conditions in uremic RLS without any severe side effects.
我们报告了睡前单次服用100 - 200毫克左旋多巴对特发性和尿毒症性不安腿综合征（RLS）患者睡眠质量、周期性腿部运动（PLM）频率及日常生活的影响。在一项随机、对照、双盲交叉试验中，对17例特发性RLS患者和11例尿毒症性（接受持续血液透析）RLS患者分别使用左旋多巴和安慰剂进行为期4周的治疗，并通过多导睡眠图、活动记录仪和主观评分进行比较评估。神经生理学评估显示，服用左旋多巴后，在睡前的前4小时内，周期性腿部运动次数（p = 0.003）和PLM指数（p = 0.005）显著降低（p = 0.001）。主观评估证实睡眠质量有所改善（p = 0.002），且患者在接受左旋多巴治疗期间白天的生活质量显著提高（p = 0.030）。我们得出结论，100 - 200毫克左旋多巴在特发性RLS中被证明是有效的，并且首次在可控条件下对尿毒症性RLS有效，且无任何严重副作用。
