Anttila R, Siimes M A
Children's Hospital, Helsinki, Finland.
Am J Clin Nutr. 1996 Feb;63(2):179-83. doi: 10.1093/ajcn/63.2.179.
We studied serum transferrin and ferritin concentrations in relation to individual body growth, stage of puberty, blood hemoglobin, and red blood cell iron (RBCI) in 60 prepubertal or early pubertal boys at 3-mo intervals for 18 mo. One-third of the boys had increased serum transferrin concentrations and almost all had decreased ferritin concentrations during the followup. No change in mean transferrin was observed but the individual 18-mo increments in transferrin correlated positively with the increments in hemoglobin (r = 0.55, P < 0.001) and in estimated RBCI (r = 0.31, P = 0.02). Serum transferrin remained stable at different genital stages, but ferritin was lower in the pubertal than in the prepubertal boys. Transferrin concentrations at 18 mo correlated positively with the preceding weight velocities. The rise in transferrin did not lead to an increase in iron-deficiency anemia. In contrast, transferrin rose in boys whose hemoglobin increased. In pubertal boys with relatively ample iron status, serum transferrin may be an indicator of increased availability of iron for erythropoiesis. The declining ferritin concentration indicates that part of the extra iron is mobilized through redistribution from stores to red blood cell mass and is generally associated with greatly increasing absorption. Thus, the pubertal changes in transferrin and ferritin are not necessarily indications of iron deficiency.
我们对60名青春期前或青春期早期男孩进行了为期18个月的研究，每隔3个月检测他们的血清转铁蛋白和铁蛋白浓度，并分析其与个体身体生长、青春期阶段、血红蛋白及红细胞铁（RBCI）的关系。在随访期间，三分之一的男孩血清转铁蛋白浓度升高，几乎所有男孩的铁蛋白浓度均下降。虽然平均转铁蛋白水平未见变化，但个体18个月内转铁蛋白的增加与血红蛋白的增加呈正相关（r = 0.55，P < 0.001），与估算的RBCI增加也呈正相关（r = 0.31，P = 0.02）。血清转铁蛋白在不同生殖器发育阶段保持稳定，但青春期男孩的铁蛋白水平低于青春期前男孩。18个月时的转铁蛋白浓度与之前的体重增长速度呈正相关。转铁蛋白升高并未导致缺铁性贫血增加。相反，血红蛋白升高的男孩转铁蛋白升高。在铁储备相对充足的青春期男孩中，血清转铁蛋白可能是红细胞生成中铁利用增加的一个指标。铁蛋白浓度下降表明部分额外的铁通过从储存部位重新分配到红细胞而被动员，这通常与铁吸收大幅增加有关。因此，青春期转铁蛋白和铁蛋白的变化不一定表明缺铁。
