Parkman H P, Harris A D, Miller M A, Fisher R S
Department of Medicine, Temple University School of Medicine, Philadelphia, Pennsylvania 19140, USA.
Am J Gastroenterol. 1996 Jan;91(1):127-33.
Dyspeptic symptoms, which are more prevalent in females, are associated with gastric myoelectric and motor abnormalities. Age, gender, and menstrual cycle affect gastric emptying, but their effects on gastric myoelectric activity are not well characterized. The aim of this study was to determine the effects of age, gender, and menstrual cycle on gastric myoelectric activity.
Healthy subjects (34 male, 49 female; ages 20-79 yr) underwent cutaneous electrogastrography with 60-min fasting and 60-min postprandial recordings. Premenopausal females were studied during days 1-3, 8-10, and 18-20 after onset of menses. Dominant slow wave frequency (DF), power of the DF, and percent time the DF was in a 2- to 4-cpm rhythm were determined for fasting and postprandial periods.
The DF, power of the DF, and percent time the DF was in a 2- to 4-cpm rhythm increased from the fasting to the postprandial period. The postprandial increase in the DF was less in females (5.3 +/- 1.2%) than in males (13.0 +/- 2.6%; p < 0.01). In premenopausal females, the DF increased from fasting to the postprandial period for days 1-3 (6.6 +/- 1.5%; p < 0.01) and 8-10 (6.6 +/- 2.3%; p < 0.01), but not during days 18-20 of the menstrual cycle (1.3 +/- 1.8%). The postprandial frequency increase in DF was less for male subjects > or = 60 yr (3.8 +/- 4.0%) than for males < 60 yr (14.6 +/- 2.8%; p < 0.05).
The DF of the electrogastrogram is affected by age, gender, and phase of the menstrual cycle. The influence of these factors should be recognized when interpreting electrogastrograms in symptomatic patients.
消化不良症状在女性中更为普遍，且与胃肌电和运动异常有关。年龄、性别和月经周期会影响胃排空，但其对胃肌电活动的影响尚未得到充分表征。本研究的目的是确定年龄、性别和月经周期对胃肌电活动的影响。
健康受试者（34名男性，49名女性；年龄20 - 79岁）在禁食60分钟和餐后60分钟进行皮肤胃电图记录。绝经前女性在月经开始后的第1 - 3天、第8 - 10天和第18 - 20天进行研究。测定禁食期和餐后期的主导慢波频率（DF）、DF的功率以及DF处于2至4次/分钟节律的时间百分比。
从禁食期到餐后期，DF、DF的功率以及DF处于2至4次/分钟节律的时间百分比均增加。餐后DF的增加在女性中（5.3±1.2%）低于男性（13.0±2.6%；p<0.01）。在绝经前女性中，月经周期第1 - 3天（6.6±1.5%；p<0.01）和第8 - 10天（6.6±2.3%；p<0.01）餐后DF增加，但在月经周期第18 - 20天未增加（1.3±1.8%）。年龄≥60岁男性受试者餐后DF频率增加（3.8±4.0%）低于年龄<60岁男性（14.6±2.8%；p<0.05）。
胃电图的DF受年龄、性别和月经周期阶段的影响。在对有症状患者的胃电图进行解读时，应认识到这些因素的影响。
