Zimina L N, Budarina I S, Nazarenko A F
Arkh Patol. 1977;39(2):51-8.
The liver and kidneys of 48 persons who had died of poisoning with ethyleneglycol were investigated at periods from 4 hours to 32 days following the poisoning. In 44 deceased who had died 2--32 days after the poising of acute renal and hepato-renal insufficiency there were revealed lesions characteristic of this intoxication. The structural basis of glycolic nephrosis and hepatosis was hydropic dystrophy of the nephrothelium of proximal and distal tubules and of hepatocytes of the centers of the liver lobules with outcome into colliquative necrosis through ballon dystrophy. Specific lesions of thekidney and liver may be accounted for by a high osmotic activity of ethyleneglycol and products of its metabolism; these were captured by the renal and hepatic epithelium in the process of reabsorption and pinocytosis increasing drastically the osmotic concentration of the intracellular liquid, which was accompanied by rapid inflow of water into the cell and its hydropic dystrophy.
对48例死于乙二醇中毒者的肝脏和肾脏进行了研究，观察时间为中毒后4小时至32天。在44例中毒后2至32天死亡的死者中，发现了急性肾和肝肾功能不全的特征性病变。乙醇酸肾病和肝病的结构基础是近端和远端肾小管的肾上皮细胞以及肝小叶中心的肝细胞出现水样变性，最终通过气球样变性发展为液化性坏死。肾脏和肝脏的特异性病变可能是由于乙二醇及其代谢产物的高渗透活性所致；它们在重吸收和胞饮过程中被肾和肝上皮细胞捕获，从而急剧增加了细胞内液的渗透浓度，同时伴随着水迅速流入细胞并导致其水样变性。
