Ganbo T, Hisamatsu K, Inoue H, Kitta Y, Nakajima M, Goto R, Murakami Y
Department of Otorhinolaryngology, Yamanashi Medical University, Japan.
Auris Nasus Larynx. 1995;22(3):158-64. doi: 10.1016/s0385-8146(12)80053-8.
Japanese cypress pollinosis has recently attracted attention and its clinical relationship with Japanese cedar pollinosis has been pointed out. To compare the two kinds of pollinosis, we retrospectively examined specific IgE antibodies to both pollen of Japanese cypress and cedar in the sera of 150 patients with nasal allergy using AlaSTAT assay. During the season in which the pollens of these two species are dispersed, the positive rates for Japanese cypress and cedar increased to 51.4 and 75.0%, respectively. The percentage of patients positive for both of cypress and cedar was elevated to 51.4%, corresponding to 68.5% of the total patient group positive for cedar. Almost all the cases positive for cypress had IgE antibodies to cedar, the value of which was considerably higher than that of cases positive only for cedar. Furthermore, increases in titers of specific IgE antibodies to cypress was observed in four of six cases, compared between specific IgE antibodies to cypress in pre- and post-dispersion of cypress pollen. These findings suggest the following possibility: (i) there is cross-antigenicity between the two pollen species, and (ii) patients are immunologically affected by cypress pollen to express higher levels of specific IgE antibodies after pollen dispersion.
日本扁柏花粉症最近受到关注，并且其与日本柳杉花粉症的临床关系也已被指出。为了比较这两种花粉症，我们使用AlaSTAT检测法对150例鼻过敏患者血清中针对日本扁柏和柳杉花粉的特异性IgE抗体进行了回顾性检测。在这两种花粉散播的季节，日本扁柏和柳杉的阳性率分别升至51.4%和75.0%。扁柏和柳杉均呈阳性的患者比例升至51.4%，占柳杉阳性患者总数的68.5%。几乎所有扁柏阳性病例都有针对柳杉的IgE抗体，其数值显著高于仅柳杉阳性的病例。此外，在六例患者中有四例，比较扁柏花粉散播前后针对扁柏的特异性IgE抗体，发现其抗体滴度有所增加。这些发现提示了以下可能性：（i）两种花粉之间存在交叉抗原性，以及（ii）患者在花粉散播后受到扁柏花粉的免疫影响，从而表达出更高水平的特异性IgE抗体。
