Dawson V L, Dawson T M
Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA.
Adv Pharmacol. 1995;34:323-42. doi: 10.1016/s1054-3589(08)61095-9.
NO has clearly revolutionized our thinking about aspects of neurotransmission and neuronal signaling. It has also radically altered our thoughts about how synaptic transmission takes place. NO is emerging as an important regulator of a variety of physiological processes; however, under certain conditions of excessive formation, NO is emerging as an important mediator of pathological nervous tissue damage. Understanding the role of NO in these processes will hopefully lead to the development of selective therapeutic agents and to a better understanding of basic processes underlying normal and pathological neuronal functions.
一氧化氮（NO）无疑彻底改变了我们对神经传递和神经元信号传导方面的看法。它也从根本上改变了我们对突触传递如何发生的认识。NO正成为多种生理过程的重要调节因子；然而，在某些生成过多的情况下，NO正成为病理性神经组织损伤的重要介质。了解NO在这些过程中的作用有望推动选择性治疗药物的研发，并有助于更好地理解正常和病理性神经元功能背后的基本过程。
