MacFaul P A, Morgan G
Br J Ophthalmol. 1977 Mar;61(3):221-8. doi: 10.1136/bjo.61.3.221.
A series of 23 eyes removed after cobalt plaque therapy for malignant melanoma of the choroid is presented, and the histological changes are described with particular reference to the presence or absence of necrosis in the tumours. In 17 of the 23 eyes no evidence of tumour necrosis was found, though all showed evidence of radiation changes in the adjacent tissues. Necrosis was found in 6 cases but was prominent in only 2, one of which was the only example of a mixed-cell tumour, the other 22 being spindle-cell tumours. Enucleation became necessary on average at about 32 months after treatment (23 out of 100 treated eyes) because of obvious failure of treatment with evidence of continued growth, or because of radiational complications leading to a painful blind eye. The 5-year survival rate was 86% compared with about 50% when the treatment is enculeation.
本文报告了23只在接受钴板治疗脉络膜恶性黑色素瘤后被摘除的眼球，并描述了其组织学变化，特别提及肿瘤中坏死的有无。在23只眼中，17只未发现肿瘤坏死的证据，尽管所有眼均显示出邻近组织的放射改变。6例发现有坏死，但仅2例坏死明显，其中1例是混合细胞肿瘤的唯一病例，另外22例是梭形细胞肿瘤。由于治疗明显失败且有持续生长的证据，或由于放射并发症导致疼痛性盲眼，平均在治疗后约32个月（100只接受治疗的眼中有23只）需要进行眼球摘除。与眼球摘除治疗时约50%的5年生存率相比，该治疗的5年生存率为86%。
