Whimbey E, Couch R B, Englund J A, Andreeff M, Goodrich J M, Raad I I, Lewis V, Mirza N, Luna M A, Baxter B
Section of Infectious Diseases, University of Texas M.D. Anderson Cancer Center, Houston 77030, USA.
Clin Infect Dis. 1995 Aug;21(2):376-9. doi: 10.1093/clinids/21.2.376.
Respiratory syncytial virus (RSV) has been demonstrated to be an important cause of life-threatening pneumonia in adult bone marrow transplant recipients; however, its role in other immunocompromised adults has not been defined. We prospectively studied all adult patients with leukemia who were hospitalized at M. D. Anderson Cancer Center (Houston) during a 1-year period (November 1993 through October 1994). During a 19-week period when RSV was prevalent in the community, it was isolated from 9 (10%) of 87 patients with leukemia who developed an acute respiratory illness. In 6 (75%) of 8 patients with profound chemotherapy-induced myelosuppression, the RSV infection was complicated by pneumonia, with an 83% mortality rate. RSV appears to be an important cause of severe and often fatal pneumonia in myelosuppressed patients with leukemia.
呼吸道合胞病毒（RSV）已被证明是成年骨髓移植受者发生危及生命的肺炎的重要原因；然而，其在其他免疫功能低下的成年人中的作用尚未明确。我们对在1年期间（1993年11月至1994年10月）于MD安德森癌症中心（休斯顿）住院的所有成年白血病患者进行了前瞻性研究。在社区中RSV流行的19周期间，从87例发生急性呼吸道疾病的白血病患者中的9例（10%）分离出了该病毒。在8例因强烈化疗导致骨髓抑制的患者中，有6例（75%）的RSV感染并发了肺炎，死亡率为83%。RSV似乎是骨髓抑制的白血病患者发生严重且往往致命的肺炎的重要原因。
