Frick O L, German D F, Mills J
J Allergy Clin Immunol. 1979 Apr;63(4):228-41. doi: 10.1016/0091-6749(79)90106-4.
Children born into allergic families, with two allergic parents, are at high risk of developing allergy within the first 5 years of life. In order to observe possible external factors in the sensitization process, a prospective study of 13 such children was done, in which serial clinical and immunologic observations were made at 3- to 6-month intervals over a period of 1 to 4 yr. Eleven of these children are now clinically allergic; 5 have asthma. Immunologic evidence for allergic sensitization was observed in these 11 children by RAST, antigen-induced leukocyte histamine release, lymphoblastogenesis, and rise in serum IgE. Upper respiratory infections (URI) occurred in these 11 allergic children 1 to 2 months prior to the onset of allergic sensitization. In 10 of these 11 URI children, complement-fixing antibodies to viruses (parainfluenza, RSV, CMV) increased in the same blood samples in which immunologic allergic sensitization was first evidenced. This coincidence suggests that certain viruses may contribute to the allergic sensitization process.
父母双方都过敏的过敏体质家庭出生的孩子，在出生后的头5年内患过敏症的风险很高。为了观察致敏过程中可能存在的外部因素，对13名这样的儿童进行了一项前瞻性研究，在1至4年的时间里，每隔3至6个月进行一系列临床和免疫学观察。其中11名儿童目前临床上患有过敏症；5名患有哮喘。通过放射变应原吸附试验（RAST）、抗原诱导的白细胞组胺释放、淋巴细胞生成以及血清IgE升高，在这11名儿童中观察到了过敏致敏的免疫学证据。上呼吸道感染（URI）在这11名过敏儿童出现过敏致敏症状前1至2个月发生。在这11名患有上呼吸道感染的儿童中，有10名儿童的病毒（副流感病毒、呼吸道合胞病毒、巨细胞病毒）补体结合抗体在首次出现免疫过敏致敏证据的同一血样中增加。这种巧合表明某些病毒可能促成了过敏致敏过程。
