van Duijnhoven H L, Treskes M
Centralized Department of Clinical Chemistry and Hematology, St. Elisabeth Hospital, Tilburg, The Netherlands.
Clin Chem. 1996 Jan;42(1):76-80.
Severe hyperglycemia can result in falsely high results for mean cell (erythrocyte) volume (MCV), which will also cause false results for erythrocyte indices calculated on the basis of MCV. Falsely high MCV results were obtained with the Technicon H1 and H2 analyzers and (to a lesser extent) with the Coulter T660. The H analyzers were more susceptible to this interference than was the Coulter T660. This difference in sensitivity of MCV to hyperglycemia can be explained by the use of sodium dodecyl sulfate in the Technicon erythrocyte diluent and by differences in incubation times. In severe hyperglycemia, results for MCV, mean cell hemoglobin concentration, and hematocrit obtained from electronic cell counters, especially Technicon H systems, are unreliable.
严重高血糖可导致平均红细胞体积（MCV）结果假性升高，这也会使基于MCV计算的红细胞指数产生错误结果。使用Technicon H1和H2分析仪可获得假性升高的MCV结果，（程度稍轻）使用库尔特T660分析仪也会出现这种情况。与库尔特T660相比，H分析仪对这种干扰更敏感。MCV对高血糖敏感性的这种差异可以通过Technicon红细胞稀释液中使用十二烷基硫酸钠以及孵育时间的差异来解释。在严重高血糖情况下，电子血细胞计数器（尤其是Technicon H系统）得出的MCV、平均红细胞血红蛋白浓度和血细胞比容结果不可靠。
