Politoske D, Ralls P, Korula J
Department of Medicine (Hepatology), University of Southern California School of Medicine, USA.
Dig Dis Sci. 1996 Jan;41(1):185-90. doi: 10.1007/BF02208603.
The association between portal vein thrombosis (PVT) and prior endoscopic variceal sclerotherapy has been suggested but remains unproven. The aim of this study was to compare the incidence of PVT in patients who had received sclerotherapy for esophageal variceal hemorrhage to a control group of cirrhotic patients with portal hypertension who had not received sclerotherapy. Doppler ultrasound was used to assess PVT in 48 patients (group 1) who had received sclerotherapy for variceal hemorrhage as well as in 52 patients (group 3) with cirrhosis and portal hypertension who had not received sclerotherapy. Assessment of PVT was made at the time of surgery in 24 patients (group 2) who had received sclerotherapy for variceal hemorrhage, failed therapy, and had portacaval shunt surgery or received liver transplantation for liver failure. One patient had splenectomy for symptoms related to a massively enlarged spleen. The incidence of PVT in group 1 was 10%, in group 2 was 13%, and in group 3 was 10%. The incidence of PVT in the three groups was not significantly different statistically. In this controlled study of patients with cirrhosis and portal hypertension, sclerotherapy does not increase the incidence of PVT.
门静脉血栓形成（PVT）与既往内镜下静脉曲张硬化治疗之间的关联已被提出，但尚未得到证实。本研究的目的是比较接受过食管静脉曲张出血硬化治疗的患者与未接受硬化治疗的肝硬化门静脉高压对照组患者中PVT的发生率。使用多普勒超声对48例接受过静脉曲张出血硬化治疗的患者（第1组）以及52例未接受硬化治疗的肝硬化和门静脉高压患者（第3组）进行PVT评估。对24例接受过静脉曲张出血硬化治疗、治疗失败且接受了门腔分流手术或因肝衰竭接受肝移植的患者（第2组）在手术时进行PVT评估。1例患者因巨脾相关症状接受了脾切除术。第1组PVT的发生率为10%，第2组为13%，第3组为10%。三组中PVT的发生率在统计学上无显著差异。在这项针对肝硬化和门静脉高压患者的对照研究中，硬化治疗不会增加PVT的发生率。
