Vincent S, Vonesch J L, Giangrande A
Institut de Génétique et Biologie Moléculaire et Cellulaire, IGBMC/CNRS/ULP-BP 163 67404 Illkirch, Strasbourg, France.
Development. 1996 Jan;122(1):131-9. doi: 10.1242/dev.122.1.131.
Glial cells constitute the second component of the nervous system and are important during neuronal development. In this paper we describe a gene, glial cell deficient, (glide), that is necessary for glial cell fate commitment in Drosophila melanogaster. Mutations at the glide locus prevent glial cell determination in the embryonic central and peripheral nervous system. Moreover, we show that the absence of glial cells is the consequence of a cell fate switch from glia to neurones. This suggests the existence of a multipotent precursor cells in the nervous system. glide mutants also display defects in axonal navigation, which confirms and extends previous results indicating a role for glial cells in these processes.
神经胶质细胞构成了神经系统的第二个组成部分，并且在神经元发育过程中起着重要作用。在本文中，我们描述了一个名为神经胶质细胞缺陷（glide）的基因，它对于黑腹果蝇神经胶质细胞命运的决定是必需的。glide基因座的突变会阻止胚胎中枢和外周神经系统中神经胶质细胞的确定。此外，我们表明神经胶质细胞的缺失是细胞命运从神经胶质细胞转变为神经元的结果。这表明神经系统中存在多能前体细胞。glide突变体在轴突导航方面也表现出缺陷，这证实并扩展了先前的结果，表明神经胶质细胞在这些过程中发挥作用。
