Hernandez T D, Warner L A, Kline A E, Kahler P J
Department of Psychology, University of Colorado, Boulder 80309, USA.
Epilepsy Res. 1995 Sep;22(1):35-41. doi: 10.1016/0920-1211(95)00036-a.
External stimuli may contribute to seizure occurrence in at least two ways. First, the aberrant neuronal activity that precipitates a seizure could be elicited by certain external events; and second, external events could cue the organism to an impending seizure and result in a compensatory response that is, in effect, 'anti-convulsant'. While previous research has been aimed at addressing these issues, the results have been inconclusive. The present study was conducted to clarify and extend this prior work. Adult male Long-Evans hooded rats were chronically implanted with a kindling electrode and randomly assigned to one of two groups. The Tone group was presented with a 2-s auditory stimulus (Tone) beginning one second prior to and overlapping with the 1-s kindling stimulus. Animals in the No Tone group received only the kindling stimulus. Antecedent tone presentation significantly delayed the rate of amygdala kindling. The Tone group required significantly more stimulations to reach a Stage 5 seizure than did the No Tone group. The possibility of this phenomenon providing a means to study the mechanisms underlying anti-epileptogenesis is discussed.
外部刺激可能至少通过两种方式促使癫痫发作。首先，引发癫痫发作的异常神经元活动可能由某些外部事件诱发；其次，外部事件可能提示机体即将发生癫痫发作，并导致一种实际上是“抗惊厥”的代偿反应。虽然先前的研究旨在解决这些问题，但其结果尚无定论。本研究旨在阐明并扩展这项先前的工作。成年雄性长 Evans 戴帽大鼠长期植入点燃电极，并随机分为两组。纯音组在 1 秒的点燃刺激开始前 1 秒呈现 2 秒的听觉刺激（纯音），且两者重叠。无纯音组的动物只接受点燃刺激。先前的纯音呈现显著延迟了杏仁核点燃的速度。纯音组达到 5 级癫痫发作所需的刺激次数明显多于无纯音组。讨论了这种现象为研究抗癫痫发生机制提供一种手段的可能性。
