Arida R M, de Jesus Vieira A, Cavalheiro E A
Neurologia Experimental, Universidade Federal de São Paulo - Escola Paulista de Medicina, SP, Brasil.
Epilepsy Res. 1998 Apr;30(2):127-32. doi: 10.1016/s0920-1211(97)00102-2.
The relationship between epilepsy and exercise is a subject of controversy and needs more investigation. We report a study of the effect of physical activity on the development of amygdala kindling in rats. To analyze the acute and chronic effects of exercise on kindling development, 45 rats were divided randomly into three groups. The first group (acute group, n=15) was submitted to a daily bout of aerobic exercise (40 min running on the treadmill at 20 m/min) and kindling stimulated 1 min post-exercise; the second group (chronic group, n=15) was submitted to an aerobic training program (40 min running on the treadmill at 20 m/min, 7 days per week, for 45 days) and then submitted to the same procedure as the first group (daily bout of aerobic exercise -- 40 min running on the treadmill at 20 m/min and kindling stimulated 1 min post-exercise); and the third group (n=15) served as control. All groups were kindling stimulated until they reached stage 5 of kindling. The number of stimulations required to reach stage 5 was statistically higher for the chronic exercise group when compared to the acute exercise group and the control group. A longer time spent in stage 1 and a shorter after-discharge duration in stage 1 was observed in the acute and chronic exercise groups in relation to the control group. This finding suggests that chronic physical exercise inhibits development of amygdala kindling in rats.
癫痫与运动之间的关系是一个存在争议的话题，需要更多的研究。我们报告了一项关于体育活动对大鼠杏仁核点燃发展影响的研究。为了分析运动对点燃发展的急性和慢性影响，将45只大鼠随机分为三组。第一组（急性组，n = 15）每天进行一次有氧运动（在跑步机上以20米/分钟的速度跑40分钟），运动后1分钟刺激点燃；第二组（慢性组，n = 15）进行有氧训练计划（在跑步机上以20米/分钟的速度跑40分钟，每周7天，共45天），然后按照与第一组相同的程序进行（每天一次有氧运动——在跑步机上以20米/分钟的速度跑40分钟，运动后1分钟刺激点燃）；第三组（n = 15）作为对照组。所有组均进行点燃刺激，直到达到点燃的第5阶段。与急性运动组和对照组相比，慢性运动组达到第5阶段所需的刺激次数在统计学上更高。与对照组相比，在急性和慢性运动组中观察到在第1阶段花费的时间更长，在第1阶段的放电后持续时间更短。这一发现表明，慢性体育锻炼会抑制大鼠杏仁核点燃的发展。
