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肠炎沙门氏菌在抗菌治疗期间体内获得超广谱β-内酰胺酶

In vivo acquisition of extended-spectrum beta-lactamase in Salmonella enteritidis during antimicrobial therapy.

作者信息

Barguellil F, Burucoa C, Amor A, Fauchère J L, Fendri C

机构信息

Laboratoire de Microbiologie, Hopital militaire de Tunis, Tunisia.

出版信息

Eur J Clin Microbiol Infect Dis. 1995 Aug;14(8):703-6. doi: 10.1007/BF01690879.

DOI:10.1007/BF01690879
PMID:8565990
Abstract

The recovery of a Salmonella enteritidis strain that acquired resistance to beta-lactams (including cefotaxime), to aminoglycosides and to chloramphenicol subsequent to cefotaxime therapy is reported. This resistance pattern to beta-lactams was due to the presence of an extended-spectrum beta-lactamase. The isoelectric point of this extended-spectrum beta-lactamase was 6.3. The resistance genes were located on a transferable high-molecular-weight plasmid.

摘要

据报道,一株肠炎沙门氏菌在接受头孢噻肟治疗后,获得了对β-内酰胺类(包括头孢噻肟)、氨基糖苷类和氯霉素的耐药性。这种对β-内酰胺类的耐药模式是由于存在一种超广谱β-内酰胺酶。这种超广谱β-内酰胺酶的等电点为6.3。耐药基因位于一个可转移的高分子量质粒上。

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Transferable resistance to third-generation cephalosporins in clinical isolates of Klebsiella pneumoniae: identification of CTX-1, a novel beta-lactamase.肺炎克雷伯菌临床分离株对第三代头孢菌素的可转移耐药性:新型β-内酰胺酶CTX-1的鉴定
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