瑞士肠杆菌科细菌中SHVβ-内酰胺酶的调查与分子遗传学研究：两种新型酶，SHV-11和SHV-12
Survey and molecular genetics of SHV beta-lactamases in Enterobacteriaceae in Switzerland: two novel enzymes, SHV-11 and SHV-12.
作者信息
Nüesch-Inderbinen M T, Kayser F H, Hächler H
机构信息
Department of Medical Microbiology, University of Zürich, Switzerland.
出版信息
Antimicrob Agents Chemother. 1997 May;41(5):943-9. doi: 10.1128/AAC.41.5.943.
Abstract
Sixty isolates of Enterobacteriaceae resistant to beta-lactam antibiotics were collected over a period of 2 years in Switzerland and screened by hybridization for the carriage of SHV genes. Thirty-four positive strains were found, and their SHV genes were amplified and sequenced. SHV extended-spectrum beta-lactamases (ESBLs) were found: 13 strains contained SHV-2a, 12 harbored SHV-2, and SHV-5 was found twice. Four strains were shown to contain SHV-1. In addition, we report two new SHV variants, termed SHV-11 (non-ESBL) and SHV-12 (ESBL). In spite of the carriage of SHV ESBLs, many strains showed only low resistance to one or more third-generation cephalosporins. In addition, 26 did not transfer the blaSHV gene in mating experiments.
摘要
在两年时间里，瑞士收集了60株对β-内酰胺类抗生素耐药的肠杆菌科细菌，并通过杂交筛选SHV基因的携带情况。发现了34株阳性菌株，对其SHV基因进行扩增和测序。发现了SHV超广谱β-内酰胺酶（ESBLs）：13株含有SHV-2a，12株含有SHV-2，SHV-5被发现两次。4株含有SHV-1。此外，我们报告了两个新的SHV变体，分别称为SHV-11（非ESBL）和SHV-12（ESBL）。尽管携带SHV ESBLs，但许多菌株对一种或多种第三代头孢菌素仅表现出低水平耐药。此外，26株在接合试验中未转移blaSHV基因。
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