McCarthy S T, Harris E, Turner R C
Diabetologia. 1977 Apr;13(2):93-7. doi: 10.1007/BF00745134.
The plasma insulin response to both a small increase and decrease in the plasma glucose has been studied in normal and diabetic, non-obese subjects. In a second investigation the plasma insulin concentrations were measured during a gradual reduction of the raised fasting plasma glucose of diabetes to normal levels. In both studies, diabetic patients were found to have a markedly impaired response of the fasting plasma insulin to small changes in plasma glucose. These results do not support the suggestion that stimulated and not basal insulin secretion is impaired in diabetes. Both modes of secretion are probably via the same B-cell release mechanism, which is deficient in diabetes. There was a gradation of response between maturity onset and juvenile onset diabetics.
在正常和非肥胖型糖尿病患者中，已经研究了血浆胰岛素对血浆葡萄糖小幅度升高和降低的反应。在第二项研究中，在将糖尿病患者升高的空腹血浆葡萄糖逐渐降至正常水平的过程中，测量了血浆胰岛素浓度。在这两项研究中，均发现糖尿病患者空腹血浆胰岛素对血浆葡萄糖小变化的反应明显受损。这些结果不支持糖尿病中受刺激而非基础胰岛素分泌受损的观点。两种分泌模式可能都通过相同的B细胞释放机制，而该机制在糖尿病中存在缺陷。成年发病型糖尿病患者和青少年发病型糖尿病患者之间存在反应梯度。
