Smits M E, Badiga S M, Rauws E A, Tytgat G N, Huibregtse K
Academic Medical Center, University of Amsterdam, Department of Gastroenterology, The Netherlands.
Gastrointest Endosc. 1995 Nov;42(5):461-7. doi: 10.1016/s0016-5107(95)70051-x.
Pancreatic stenting is a new nonsurgical treatment for patients with chronic pancreatitis and pain. We studied the long-term safety and efficacy of pancreatic stenting.
Between 1982 and 1993, 51 patients with chronic pancreatitis and persistent pain with dominant strictures in the pancreatic duct were treated with plastic pancreatic stents.
Stent insertion was successful in 49 of 51 patients. Early complications occurred in 9 of the 51 patients (18%). Patients were followed for a median of 34 months (range 6 to 128). Nine of the 49 patients (82%) had clinical improvement. Sixteen of these 40 patients still had their stents in place. Stents were removed in 22 of the 40 patients with persistent beneficial response in all (median follow-up 28.5 months). The long-term effect of stenting could not be evaluated in the remaining 2 patients because they had a double bypass operation. Stent dysfunction occurred in 27 of the 49 patients (55%) and was successfully treated by exchanging the stent.
Pancreatic stenting was associated with minimal early complications, but stent dysfunction remained a frequent late complication. Pancreatic drainage resulted in clinical improvement in 40 of the 49 patients (82%). Twenty-two of these 40 patients maintained the beneficial response after stent removal (28.5 months).
胰腺支架置入术是一种针对慢性胰腺炎伴疼痛患者的新型非手术治疗方法。我们研究了胰腺支架置入术的长期安全性和有效性。
1982年至1993年间，51例慢性胰腺炎伴持续性疼痛且主胰管存在明显狭窄的患者接受了塑料胰腺支架置入治疗。
51例患者中有49例支架置入成功。51例患者中有9例（18%）发生早期并发症。患者的中位随访时间为34个月（范围6至128个月）。49例患者中有9例（82%）临床症状改善。这40例患者中有16例仍保留支架。40例持续有良好反应的患者中有22例（全部患者中位随访28.5个月）取出了支架。其余2例患者因接受了双旁路手术，无法评估支架置入的长期效果。49例患者中有27例（55%）发生支架功能障碍，通过更换支架成功治疗。
胰腺支架置入术早期并发症极少，但支架功能障碍仍是常见的晚期并发症。49例患者中有40例（82%）经胰腺引流后临床症状改善。这40例患者中有22例在取出支架后（28.5个月）仍保持良好反应。
