Schöön I M, Olbe L
Gut. 1978 Jan;19(1):27-31. doi: 10.1136/gut.19.1.27.
Vagal activation of gastric acid secretion by modified sham feeding in six patients with duodenal ulcer produced a peak acid response amounting to 52% of the peak acid output after pentagastrin stimulation (PAOpg). Cholinergic reflex stimulation of gastric acid secretion by fundic distension in another six patients with duodenal ulcer produced a peak acid response of 45% of PAOpg. Intravenous infusion of cimetidine in a dose of 100 mg/h markedly inhibited the acid sham feeding response by 90-100% and almost abolished the acid response to fundic distension. The results suggest that gastric acid secretion evoked by physiological vagal activation in man is profoundly inhibited by H2-receptor blocking agents.
在6例十二指肠溃疡患者中,通过改良假饲刺激迷走神经来激活胃酸分泌,所产生的胃酸反应峰值相当于五肽胃泌素刺激后最大酸排出量(PAOpg)的52%。在另外6例十二指肠溃疡患者中,通过胃底扩张来进行胆碱能反射刺激胃酸分泌,所产生的胃酸反应峰值为PAOpg的45%。以100毫克/小时的剂量静脉输注西咪替丁,可显著抑制假饲引起的胃酸反应达90%-100%,并几乎消除对胃底扩张的胃酸反应。结果表明,人通过生理性迷走神经激活引起的胃酸分泌受到H2受体阻断剂的显著抑制。