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1
Inhibitory effect of cimetidine on gastric acid secretion vagally activated by physiological means in duodenal ulcer patients.西咪替丁对十二指肠溃疡患者经生理途径迷走神经激活所致胃酸分泌的抑制作用。
Gut. 1978 Jan;19(1):27-31. doi: 10.1136/gut.19.1.27.
2
Studies on vagal activation of gastric acid secretion in man.关于人体迷走神经对胃酸分泌激活作用的研究。
Acta Physiol Scand Suppl. 1979;465:1-31.
3
Effect of cimetidine on pentagastrin-stimulated gastric acid and pepsin secretion before and after 6 weeks of cimetidine treatment.西咪替丁治疗6周前后，西咪替丁对五肽胃泌素刺激的胃酸和胃蛋白酶分泌的影响。
Scand J Gastroenterol. 1978;13(2):193-7. doi: 10.3109/00365527809181747.
4
Effect of atropine and proximal gastric vagotomy on the acid response to fundic distension in man.阿托品和近端胃迷走神经切断术对人体胃底扩张酸反应的影响。
Gut. 1977 Apr;18(4):303-10. doi: 10.1136/gut.18.4.303.
5
Cephalic phase of gastric secretion in healthy subjects and duodenal ulcer patients: role of vagal innervation.健康受试者和十二指肠溃疡患者胃酸分泌的头期：迷走神经支配的作用。
Gut. 1979 Oct;20(10):875-81. doi: 10.1136/gut.20.10.875.
6
Effect of cimetidine on pentagastrin-stimulated gastric secretion before and after proximal gastric vagotomy for duodenal ulcer.西咪替丁对十二指肠溃疡近端胃迷走神经切断术前、后五肽胃泌素刺激的胃分泌的影响。
Scand J Gastroenterol. 1978;13(6):679-84. doi: 10.3109/00365527809181781.
7
Effect of fundic distension on gastric acid secretion in man.胃底扩张对人体胃酸分泌的影响。
Gut. 1977 Feb;18(2):105-10. doi: 10.1136/gut.18.2.105.
8
Parietal and chief cell sensitivity to pentagastrin stimulation before and after cimetidine treatment for duodenal ulcer.十二指肠溃疡患者在西咪替丁治疗前后壁细胞和主细胞对五肽胃泌素刺激的敏感性。
Scand J Gastroenterol. 1979;14(1):111-14. doi: 10.3109/00365527909179855.
9
Effect of cimetidine on histamine- and pentagastrin-stimulated gastric secretion in healthy subjects.西咪替丁对健康受试者组胺和五肽胃泌素刺激的胃酸分泌的影响。
Scand J Gastroenterol. 1979;14(3):367-72. doi: 10.3109/00365527909179898.
10
Comparison of intraduodenal and intravenous administration of amino acids on gastric secretion in healthy subjects and patients with duodenal ulcer.健康受试者和十二指肠溃疡患者十二指肠内和静脉注射氨基酸对胃酸分泌影响的比较。
Gut. 1978 Oct;19(10):859-64. doi: 10.1136/gut.19.10.859.

引用本文的文献

1
Vagal effects on acid and pepsin secretion and serum gastrin in duodenal ulcer and controls.迷走神经对十二指肠溃疡患者及对照组胃酸、胃蛋白酶分泌和血清胃泌素的影响。
Dig Dis Sci. 1993 Oct;38(10):1874-84. doi: 10.1007/BF01296112.
2
Use and abuse of H2 receptor antagonists.H2受体拮抗剂的使用与滥用
J R Coll Physicians Lond. 1982 Jan;16(1):33-9.
3
A long lasting gastrin response to apomorphine revealed by inhibitors of gastric acid secretion.胃酸分泌抑制剂揭示的对阿扑吗啡的持久胃泌素反应。
Naunyn Schmiedebergs Arch Pharmacol. 1987 Jul;336(1):20-4. doi: 10.1007/BF00177746.
4
Effect of proximal gastric vagotomy and anticholinergics on the acid and gastrin responses to sham feeding in duodenal ulcer patients.近端胃迷走神经切断术和抗胆碱能药物对十二指肠溃疡患者假饲时胃酸和胃泌素反应的影响。
Gut. 1979 Nov;20(11):1020-7. doi: 10.1136/gut.20.11.1020.

本文引用的文献

1
Stimulation of secretion of acid by distention of denervated fundic pouches in dogs.狗去神经支配胃底袋扩张对胃酸分泌的刺激作用。
Gastroenterology. 1961 Oct;41:385-90.
2
Secretion of acid and pepsin in response to distention of vagally innervated fundic gland area in dogs.犬迷走神经支配的胃底腺区扩张时酸和胃蛋白酶的分泌
Gastroenterology. 1962 Jun;42:718-21.
3
The effect of exogenous gastrin on the acid sham feeding response in antrum-bulb-resected duodenal ulcer patients.外源性胃泌素对胃窦-球部切除的十二指肠溃疡患者胃酸假饲反应的影响。
Scand J Gastroenterol. 1974;9(3):231-8.
4
Gastric acid response to sham feeding before and after resection of antrum and duodenal bulb in duodenal ulcer patients.十二指肠溃疡患者胃窦和十二指肠球部切除前后假饲引起的胃酸反应。
Scand J Gastroenterol. 1974;9(2):191-201.
5
Definition and antagonism of histamine H 2 -receptors.组胺H2受体的定义与拮抗作用。
Nature. 1972 Apr 21;236(5347):385-90. doi: 10.1038/236385a0.
6
Influence of feeding and sham feeding upon serum gastrin and gastric acid secretion in control subjects and duodenal ulcer patients.进食和假进食对健康受试者及十二指肠溃疡患者血清胃泌素和胃酸分泌的影响。
Scand J Gastroenterol. 1974 Nov;9(8):703-10.
7
Gastric acid and plasma gastrin responses to sham feeding in duodenal ulcer patients before and after resection of antrum and duodenal bulb.十二指肠溃疡患者在胃窦和十二指肠球部切除术前、后假饲时胃酸和血浆胃泌素的反应。
Scand J Gastroenterol. 1974;9(4):351-6.
8
Action of Burimamide, a histamine antagonist, on acid secretion in vitro.组胺拮抗剂布立马胺对胃酸分泌的体外作用。
Am J Physiol. 1974 Apr;226(4):898-902. doi: 10.1152/ajplegacy.1974.226.4.898.
9
Aspects of the effect of metiamide on pentagastrin-stimulated and basal gastric secretion of acid and pepsin in man.甲硫米特对人五肽胃泌素刺激的胃酸和胃蛋白酶基础分泌的影响的相关方面。
Gut. 1975 Jul;16(7):501-8. doi: 10.1136/gut.16.7.501.
10
Metiamide inhibits canine gastric acid secretion evoked by sham feeding.甲硫米特抑制假饲诱发的犬胃酸分泌。
Scand J Gastroenterol. 1976;11(6):559-60.

西咪替丁对十二指肠溃疡患者经生理途径迷走神经激活所致胃酸分泌的抑制作用。

Inhibitory effect of cimetidine on gastric acid secretion vagally activated by physiological means in duodenal ulcer patients.

作者信息

Schöön I M, Olbe L

出版信息

Gut. 1978 Jan;19(1):27-31. doi: 10.1136/gut.19.1.27.

DOI:10.1136/gut.19.1.27
PMID:624502
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1411771/
Abstract

Vagal activation of gastric acid secretion by modified sham feeding in six patients with duodenal ulcer produced a peak acid response amounting to 52% of the peak acid output after pentagastrin stimulation (PAOpg). Cholinergic reflex stimulation of gastric acid secretion by fundic distension in another six patients with duodenal ulcer produced a peak acid response of 45% of PAOpg. Intravenous infusion of cimetidine in a dose of 100 mg/h markedly inhibited the acid sham feeding response by 90-100% and almost abolished the acid response to fundic distension. The results suggest that gastric acid secretion evoked by physiological vagal activation in man is profoundly inhibited by H2-receptor blocking agents.

摘要

在6例十二指肠溃疡患者中，通过改良假饲刺激迷走神经来激活胃酸分泌，所产生的胃酸反应峰值相当于五肽胃泌素刺激后最大酸排出量（PAOpg）的52%。在另外6例十二指肠溃疡患者中，通过胃底扩张来进行胆碱能反射刺激胃酸分泌，所产生的胃酸反应峰值为PAOpg的45%。以100毫克/小时的剂量静脉输注西咪替丁，可显著抑制假饲引起的胃酸反应达90%-100%，并几乎消除对胃底扩张的胃酸反应。结果表明，人通过生理性迷走神经激活引起的胃酸分泌受到H2受体阻断剂的显著抑制。