Ishida Yuko, Nosaka Mizuho, Kondo Toshikazu
Department of Forensic Medicine, Wakayama Medical University, Wakayama, Japan.
Front Med (Lausanne). 2022 Jan 27;9:822572. doi: 10.3389/fmed.2022.822572. eCollection 2022.
Appropriate technology as well as specific target cells and molecules are key factors for determination of wound vitality or wound age in forensic practice. Wound examination is one of the most important tasks for forensic pathologists and is indispensable to distinguish antemortem wounds from postmortem damage. For vital wounds, estimating the age of the wound is also essential in determining how the wound is associated with the cause of death. We investigated bone marrow-derived cells as promising markers and their potential usefulness in forensic applications. Although examination of a single marker cannot provide high reliability and objectivity in estimating wound age, evaluating the appearance combination of bone marrow-derived cells and the other markers may allow for a more objective and accurate estimation of wound age.
合适的技术以及特定的靶细胞和分子是法医实践中确定伤口活力或伤口形成时间的关键因素。伤口检查是法医病理学家最重要的任务之一，对于区分生前伤口和死后损伤必不可少。对于生前伤口，估计伤口形成时间对于确定伤口与死亡原因的关联也至关重要。我们研究了骨髓来源的细胞作为有前景的标志物及其在法医应用中的潜在用途。尽管单一标志物的检查在估计伤口形成时间时不能提供高可靠性和客观性，但评估骨髓来源的细胞与其他标志物的外观组合可能会使伤口形成时间的估计更加客观和准确。
