Dawson G, Klinger L G, Panagiotides H, Lewy A, Castelloe P
Department of Psychology, University of Washington, Seattle 98195, USA.
J Abnorm Child Psychol. 1995 Oct;23(5):569-83. doi: 10.1007/BF01447662.
Two questions were addressed in the present study: (1) Do autistic and normally developing children exhibit regionally specific differences in electroencephalographic (EEG) activity? (2) Do subgroups of autistic children classified according to Wing and Gould's (1979) system which emphasizes degree of social impairment exhibit distinct patterns of EEG activity? Twenty-eight children with autism (5 to 18 years of age) and two groups of normally developing children (one matched on chronological age and the other on receptive language level) participated. EEG was recorded from left and right frontal, temporal, and parietal regions during an alert baseline condition. Compared to normally developing children, autistic children exhibited reduced EEG power in the frontal and temporal regions, but not in the parietal region. Differences were more prominent in the left than the right hemisphere. Furthermore, subgroups of autistic children based on Wing and Gould's system displayed distinct patterns of brain activity. Compared to autistic children classified as "active-but-odd," "passive" autistic children displayed reduced alpha EEG power in the frontal region.
（1）自闭症儿童和正常发育儿童在脑电图（EEG）活动上是否存在区域特异性差异？（2）根据温格和古尔德（1979年）强调社会障碍程度的系统分类的自闭症儿童亚组，其EEG活动模式是否不同？28名自闭症儿童（5至18岁）和两组正常发育儿童（一组按实际年龄匹配，另一组按接受性语言水平匹配）参与了研究。在警觉基线状态下，从左右额叶、颞叶和顶叶区域记录EEG。与正常发育儿童相比，自闭症儿童在额叶和颞叶区域的EEG功率降低，但在顶叶区域没有。差异在左半球比右半球更明显。此外，基于温格和古尔德系统的自闭症儿童亚组表现出不同的脑活动模式。与被归类为“活跃但怪异”的自闭症儿童相比，“被动”自闭症儿童在额叶区域的α波EEG功率降低。
