Gorse G J, Otto E E, Powers D C, Chambers G W, Eickhoff C S, Newman F K
Division of Infectious Diseases and Immunology and Geriatric Research, St. Louis VA Medical Center, Missouri, USA.
J Infect Dis. 1996 Feb;173(2):285-90. doi: 10.1093/infdis/173.2.285.
Induction of local antibody responses to influenza A virus hemagglutinin by coadministration of two vaccines was investigated. Fifty elderly nursing home residents received inactivated trivalent influenza virus vaccine intramuscularly and simultaneously were randomized to receive either bivalent live attenuated influenza A virus vaccine or saline placebo intranasally in a blinded fashion. More significant increases in anti-H1 and -H3 IgA antibodies were detectable in nasal wash specimens of subjects who received live attenuated virus vaccine than in those who received intranasal placebo. The increased anti-hemagglutinin IgA antibody response was of longer duration in recipients of live attenuated vaccine. The change in antibody titers after vaccination was positively correlated with total blood lymphocyte counts measured before vaccination in both vaccinee groups (P < .05). There was a possible advantage of administering live attenuated with inactivated virus vaccines because of enhanced local antibody responses.
研究了两种疫苗联合接种诱导对甲型流感病毒血凝素的局部抗体反应。五十名老年疗养院居民接受了肌肉注射的灭活三价流感病毒疫苗，同时被随机分为以盲法鼻内接受二价减毒活甲型流感病毒疫苗或盐水安慰剂。接受减毒活病毒疫苗的受试者鼻洗液标本中检测到的抗H1和-H3 IgA抗体的增加比接受鼻内安慰剂的受试者更显著。减毒活疫苗接种者中抗血凝素IgA抗体反应的增加持续时间更长。两个疫苗接种组中，接种疫苗后抗体滴度的变化与接种前测量的全血淋巴细胞计数呈正相关（P < .05）。由于增强了局部抗体反应，联合接种减毒活疫苗和灭活病毒疫苗可能具有优势。
