Gorse G J, Campbell M J, Otto E E, Powers D C, Chambers G W, Newman F K
Division of Infectious Diseases and Immunology, St. Louis VA Medical Center, Missouri, USA.
J Infect Dis. 1995 Jul;172(1):1-10. doi: 10.1093/infdis/172.1.1.
The possible enhancement of anti-influenza A virus memory cytotoxic T cell (CTL) responses to inactivated influenza virus vaccine by coadministration of intranasal live attenuated influenza A virus vaccine was investigated. Fifty elderly nursing home residents received inactivated trivalent influenza virus vaccine intramuscularly and simultaneously were randomly assigned to receive either bivalent live attenuated influenza A virus vaccine or saline placebo intranasally in a blinded fashion. A larger proportion of volunteers who received live attenuated virus vaccine than of those who received placebo experienced a postvaccination rise in anti-influenza A virus CTL activity (15 of 23 vs. 8 of 24; P < .05). Anti-influenza A virus cytotoxicity was primarily mediated by CD8+ T cells and was influenza A virus-specific and HLA-restricted. There was a possible advantage of administering live attenuated with inactivated virus vaccine because of enhanced memory anti-influenza A virus CTL activity.
研究了通过鼻内接种减毒活甲型流感病毒疫苗与灭活甲型流感病毒疫苗共同给药，是否可能增强抗甲型流感病毒记忆性细胞毒性T细胞（CTL）反应。50名老年疗养院居民接受了肌肉注射的灭活三价流感病毒疫苗，同时被随机分配以盲法鼻内接受二价减毒活甲型流感病毒疫苗或生理盐水安慰剂。接受减毒活病毒疫苗的志愿者比接受安慰剂的志愿者中，有更大比例在接种疫苗后抗甲型流感病毒CTL活性升高（23人中的15人 vs. 24人中的8人；P < 0.05）。抗甲型流感病毒细胞毒性主要由CD8 + T细胞介导，且具有甲型流感病毒特异性和HLA限制性。由于增强了记忆性抗甲型流感病毒CTL活性，联合使用减毒活疫苗和灭活病毒疫苗可能具有优势。
