Kulin H E, Santner S J
J Pediatr. 1977 May;90(5):760-5. doi: 10.1016/s0022-3476(77)81243-2.
Timed urine collections-mostly over a three-hour period-were obtained from 58 newborn, 68 prepubertal children, 27 adolescents, and 51 adults. For comparison, similar samples were collected from 69 patients with presumptive abnormalities of sexual maturation. Follicle-stimulating hormone and luteinizing hormone were extracted by acetone precipitation and measured by radioimmunossay. Adult nem and women excreted approximately 11 times as much FSH and 33 times as much LH as perpubertal children. Elevated and/or diminished excretory values of gonadotropins were associated with appropriate diagnoses of abnormal pubertal advance or delay. Timed urinary FSH and LH measurements can provide a simple, sensitive, and accurate test of gonadotropin function in children.
对58名新生儿、68名青春期前儿童、27名青少年和51名成年人进行了定时尿液收集（大部分为三小时时段）。作为对照，从69名性成熟疑似异常的患者中收集了类似样本。促卵泡激素和促黄体生成素通过丙酮沉淀法提取，并采用放射免疫测定法进行测量。成年男性和女性排泄的促卵泡激素量约为青春期前儿童的11倍，促黄体生成素量约为33倍。促性腺激素排泄值的升高和/或降低与青春期提前或延迟异常的适当诊断相关。定时尿液促卵泡激素和促黄体生成素测量可为儿童促性腺激素功能提供一种简单、灵敏且准确的检测方法。
