组织残留的药代动力学预测。

Pharmacokinetic prediction of tissue residues.

作者信息

Dittert L W

出版信息

J Toxicol Environ Health. 1977 Mar;2(4):735-56. doi: 10.1080/15287397709529477.

Abstract

The applications of pharmacokinetic modeling to the prediction of tissue residues of drugs in food-producing animals are reviewed. The properties of the one-compartment open model are discussed, and the application of this model to the serum levels, urine outputs, and tissue residues of sulfamethazine and its metabolites in sheep is described. The properties of the two-compartment model are discussed, and the application of this model to the serum levels and urine outputs of dicloxacillin in humans is described. Complexities encountered with drugs such as pentobarbital, the tetracyclines, etidronate, and salicylate are discussed as examples of pharmacokinetic behavior that make both modeling and tissue residue prediction difficult.

摘要

综述了药代动力学模型在预测食用动物体内药物组织残留方面的应用。讨论了单室开放模型的特性，并描述了该模型在绵羊体内磺胺二甲嘧啶及其代谢物的血清水平、尿量和组织残留残留残留中的应用。讨论了双室模型的特性，并描述了该模型在人类双氯西林血清水平和尿量中的应用。以戊巴比妥、四环素、依替膦酸盐和水杨酸盐等药物为例，讨论了药代动力学行为中遇到的复杂性，这些复杂性使得建模和组织残留预测都很困难。